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met MET proto-oncogene, receptor tyrosine kinase [ Danio rerio (zebrafish) ]

Gene ID: 100150664, updated on 6-May-2021

Summary

Official Symbol
metprovided by ZNC
Official Full Name
MET proto-oncogene, receptor tyrosine kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041014-1
See related
Ensembl:ENSDARG00000070903
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
don; cmet; c-met
Orthologs
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Genomic context

See met in Genome Data Viewer
Location:
chromosome: 25
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (18583714..18681725)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (18487340..18583219)
103 previous assembly Zv9 (GCF_000002035.4) 25 NC_007136.5 (19071038..19166357)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene caveolin 2 Neighboring gene caveolin 1 Neighboring gene si:dkeyp-93a5.2 Neighboring gene family with sequence similarity 185 member A

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables hepatocyte growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables semaphorin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within central nervous system neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar granule cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within exocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in liver development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within liver development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pancreas development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within pectoral fin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within semaphorin-plexin signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
hepatocyte growth factor receptor
Names
met proto-oncogene (hepatocyte growth factor receptor)
NP_001007125.1
XP_005163051.1
XP_005163052.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007124.1NP_001007125.1  hepatocyte growth factor receptor precursor

    See identical proteins and their annotated locations for NP_001007125.1

    Status: PROVISIONAL

    Source sequence(s)
    AY687384
    UniProtKB/TrEMBL
    Q64GK4
    Related
    ENSDARP00000152967.1, ENSDART00000180287.1
    Conserved Domains (6) summary
    cd11248
    Location:43511
    Sema_MET_like; The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases
    smart00423
    Location:514559
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:654736
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:10831344
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam07714
    Location:10791338
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:562653
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    18583714..18681725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162995.4XP_005163052.1  hepatocyte growth factor receptor isoform X2

    Conserved Domains (6) summary
    cd11248
    Location:43511
    Sema_MET_like; The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases
    smart00423
    Location:514559
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:654736
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:10361297
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam07714
    Location:10321291
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:562653
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  2. XM_005162994.4XP_005163051.1  hepatocyte growth factor receptor isoform X1

    UniProtKB/TrEMBL
    F1QLR7
    Related
    ENSDARP00000123904.1, ENSDART00000148741.2
    Conserved Domains (6) summary
    cd11248
    Location:43511
    Sema_MET_like; The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases
    smart00423
    Location:514559
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:654736
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:10831344
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam07714
    Location:10791338
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:562653
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
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