hscb HscB mitochondrial iron-sulfur cluster cochaperone [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hscbprovided by ZNC
Official Full Name: HscB mitochondrial iron-sulfur cluster cochaperoneprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-97
See related: Ensembl:ENSDARG00000075416 AllianceGenome:ZFIN:ZDB-GENE-070705-97
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:ch211-207k7.4
Summary: Predicted to enable ATPase activator activity and chaperone binding activity. Predicted to be involved in [2Fe-2S] cluster assembly. Predicted to act upstream of or within protein complex oligomerization and protein maturation by iron-sulfur cluster transfer. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (10084100..10093431)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (9579462..9588793)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATPase activator activity	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in [2Fe-2S] cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within [2Fe-2S] cluster assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein complex oligomerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: iron-sulfur cluster co-chaperone protein HscB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128398.1 → NP_001121870.1 iron-sulfur cluster co-chaperone protein HscB

Status: PROVISIONAL

Source sequence(s)

CR854962

UniProtKB/TrEMBL

A0A8M1NK32, B0V1J6

Related

ENSDARP00000098896.3, ENSDART00000109236.4

Conserved Domains (3) summary

PRK05014
Location:104 → 259

hscB; co-chaperone HscB; Provisional

smart00271
Location:102 → 167

DnaJ; DnaJ molecular chaperone homology domain

pfam07743
Location:189 → 260

HSCB_C; HSCB C-terminal oligomerization domain