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mhc1lja major histocompatibility complex class I LJA [ Danio rerio (zebrafish) ]

Gene ID: 100150018, updated on 9-Dec-2024

Summary

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Official Symbol
mhc1ljaprovided by ZNC
Official Full Name
major histocompatibility complex class I LJAprovided by ZNC
Primary source
ZFIN:ZDB-GENE-140820-11
See related
Ensembl:ENSDARG00000096830 AllianceGenome:ZFIN:ZDB-GENE-140820-11
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-147g22.3
Summary
Predicted to be involved in immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); eye disease (multiple); inner ear disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including CD1A (CD1a molecule); CD1B (CD1b molecule); and CD1C (CD1c molecule). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mhc1lja in Genome Data Viewer
Location:
chromosome: 25
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (10913748..10918316)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (10816952..10821520)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene si:ch211-147g22.4 Neighboring gene class I histocompatibility antigen, F10 alpha chain Neighboring gene major histocompatibility complex class I-related gene protein Neighboring gene major histocompatibility complex class I-related gene protein-like Neighboring gene major histocompatibility complex class I LEA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The MHC class I genes of zebrafish. Dirscherl H, et al. Dev Comp Immunol, 2014 Sep. PMID 24631581, Free PMC Article
  2. A draft genome of the striped catfish, Pangasianodon hypophthalmus, for comparative analysis of genes relevant to development and a resource for aquaculture improvement. Kim OTP, et al. BMC Genomics, 2018 Oct 5. PMID 30290758, Free PMC Article
  3. Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. McConnell SC, et al. Sci Rep, 2023 May 13. PMID 37179373, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
major histocompatibility complex class I LJA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001327918.1 → NP_001314847.1  major histocompatibility complex class I LJA precursor

    Status: VALIDATED

    Source sequence(s)
    CR339041
    UniProtKB/TrEMBL
    A0A8M1P990, X1WF83
    Related
    ENSDARP00000128887.1, ENSDART00000153472.2
    Conserved Domains (1) summary
    cd07698
    Location:194 → 290
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    10913748..10918316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials