akt3b v-akt murine thymoma viral oncogene homolog 3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: akt3bprovided by ZNC
Official Full Name: v-akt murine thymoma viral oncogene homolog 3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-110309-3
See related: Ensembl:ENSDARG00000087205 AllianceGenome:ZFIN:ZDB-GENE-110309-3
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: akt3
Summary: Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within regulation of blood vessel endothelial cell differentiation. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	1	NC_133176.1 (57177541..57202306, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (53732096..53756863, complement)

Chromosome 1 - NC_133176.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood vessel endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of blood vessel endothelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Names: v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

XP_001923454.3

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The following sections contain reference sequences that belong to a specific genome build. Explain