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grin2db glutamate receptor, ionotropic, N-methyl D-aspartate 2D, b [ Danio rerio (zebrafish) ]

Gene ID: 100149482, updated on 15-Jul-2026
Official Symbol
grin2dbprovided by ZNC
Official Full Name
glutamate receptor, ionotropic, N-methyl D-aspartate 2D, bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100920-7
See related
Ensembl:ENSDARG00000070620 AllianceGenome:ZFIN:ZDB-GENE-100920-7
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
NR2D.1; si:dkey-209f7.2
Summary
Is expressed in forebrain; hindbrain; midbrain; presumptive neural retina; and spinal cord. [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See grin2db in Genome Data Viewer
Location:
chromosome: 16
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 16 NC_133191.1 (13543021..13840630, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 16 NC_007127.7 (13176761..13388725, complement)

Chromosome 16 - NC_133191.1Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, gamma subunit 7b Neighboring gene protein kinase C, gamma Neighboring gene phosphatidylinositol transfer protein cytoplasmic 1b Neighboring gene si:dkeyp-69b9.3 Neighboring gene uncharacterized LOC141378342 Neighboring gene uncharacterized LOC101883024

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish. Zoodsma JD, et al. Mol Autism, 2022 Sep 22. PMID 36138431, Free PMC Article
  2. Understanding similarities and differences of FASD in three zebrafish populations. Mamede JPM, et al. Neurotoxicology, 2026 Jan. PMID 41421766
  3. Evaluation of age-dependent response to NMDA receptor antagonism in zebrafish. Menezes FP, et al. Zebrafish, 2015 Apr. PMID 25602300
  4. Molecular characterization and embryonic expression of the family of N-methyl-D-aspartate receptor subunit genes in the zebrafish. Cox JA, et al. Dev Dyn, 2005 Nov. PMID 16123982
  5. Strain dependent gene expression and neurochemical levels in the brain of zebrafish: focus on a few alcohol related targets. Pan Y, et al. Physiol Behav, 2012 Dec 5. PMID 22313674, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NMDA glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
uncharacterized protein grin2db
Names
glutamate receptor ionotropic, NMDA 2D

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133191.1 Reference GRCz12tu Primary Assembly

    Range
    13543021..13840630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073925936.1 → XP_073782037.1  uncharacterized protein grin2db isoform X2

    UniProtKB/TrEMBL
    A0A8M3AT83, A0AC58HJ67, A0AC58HJ89, A0AC58HJB5

  2. XM_073925938.1 → XP_073782039.1  uncharacterized protein grin2db isoform X2

    UniProtKB/TrEMBL
    A0A8M3AT83, A0AC58HJ67, A0AC58HJ89, A0AC58HJB5

  3. XM_073925935.1 → XP_073782036.1  uncharacterized protein grin2db isoform X2

    UniProtKB/TrEMBL
    A0A8M3AT83, A0AC58HJ67, A0AC58HJ89, A0AC58HJB5

  4. XM_009292142.5 → XP_009290417.1  uncharacterized protein grin2db isoform X2

    UniProtKB/TrEMBL
    A0A8M3AT83, A0AC58HJ67, A0AC58HJ89, A0AC58HJB5
    Related
    ENSDARP00000094658.5
    Conserved Domains (6) summary
    cd06378
    Location:44 → 421
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    COG0834
    Location:487 → 570
    HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
    cd13718
    Location:433 → 831
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:585 → 857
    Lig_chan; Ligand-gated ion channel
    pfam10565
    Location:868 → 900
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
    pfam16046
    Location:1763 → 1856
    FAM76; FAM76 protein

  5. XM_073925934.1 → XP_073782035.1  uncharacterized protein grin2db isoform X1

    UniProtKB/TrEMBL
    A0AC58HJ75
Nucleotide Protein Strain
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