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DMRT3 doublesex and mab-3 related transcription factor 3 [ Equus caballus (horse) ]

Gene ID: 100147177, updated on 8-Aug-2025
Gene symbol
DMRT3
Gene description
doublesex and mab-3 related transcription factor 3
See related
Ensembl:ENSECAG00000023412
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
all
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Try the new Transcripts and proteins table
See DMRT3 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_12 current TB-T2T (GCF_041296265.1) 23 NC_091706.1 (36112086..36126197)
RS_2024_08 previous assembly EquCab3.0 (GCF_002863925.1) 23 NC_009166.3 (22378399..22392510)

Chromosome 23 - NC_091706.1Genomic Context describing neighboring genes Neighboring gene KN motif and ankyrin repeat domains 1 Neighboring gene uncharacterized LOC102147582 Neighboring gene doublesex and mab-3 related transcription factor 1 Neighboring gene doublesex and mab-3 related transcription factor 2 Neighboring gene ubiquitin-ribosomal protein eS31 fusion protein-like

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Thoroughbred Stallion gene expression
  • BioProject: PRJEB53382
  • Analysis date: Mon Jan 06 09:53:19 2025

Related articles in PubMed

  1. Stock-type equine disciplines Hunter, Reining and Roping are associated with the A allele at the DMRT3 locus for gait phenotypes in the horse. Patterson Rosa L, et al. Anim Genet, 2021 Oct. PMID 34250625
  2. The effect of the 'Gait keeper' mutation in the DMRT3 gene on gaiting ability in Icelandic horses. Kristjansson T, et al. J Anim Breed Genet, 2014 Dec. PMID 25073639
  3. The DMRT3 'Gait keeper' mutation affects performance of Nordic and Standardbred trotters. Jäderkvist K, et al. J Anim Sci, 2014 Oct. PMID 25085403
  4. DMRT3 is associated with gait type in Mangalarga Marchador horses, but does not control gait ability. Patterson L, et al. Anim Genet, 2015 Apr. PMID 25690906
  5. Does heterozygosity at the DMRT3 gene make French trotters better racers? Ricard A. Genet Sel Evol, 2015 Feb 26. PMID 25886871, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and characterization of single nucleotide polymorphisms in DMRT3 gene in Indian horse (Equus caballus) and donkey (Equus asinus) populations.
    Title: Identification and characterization of single nucleotide polymorphisms in DMRT3 gene in Indian horse (Equus caballus) and donkey (Equus asinus) populations.
  2. Stock-type equine disciplines Hunter, Reining and Roping are associated with the A allele at the DMRT3 locus for gait phenotypes in the horse.
    Title: Stock-type equine disciplines Hunter, Reining and Roping are associated with the A allele at the DMRT3 locus for gait phenotypes in the horse.
  3. The results indicated that there are significant kinematic and DMRT3 differences between the Colombian paso horse's gaits, and those parameters can be used partially to select and control the horses gait performance. However, the DMRT3 gene does not play a major role in controlling the trocha and the Colombian trot gaits. Therefore, modifying genes likely influence these gaits.
    Title: Selection on the Colombian paso horse's gaits has produced kinematic differences partly explained by the DMRT3 gene.
  4. All Hokkaido Native Horses exhibiting pace were AA for DMRT3:Ser301Ter, confirming the association of DMRT3:Ser301Ter with gait determination; however, 14.3% of the animals exhibiting trot also had AA for DMRT3:Ser301Ter, suggesting the presence of another factor(s) cooperatively working with DMRT3:Ser301Ter for gait determination.
    Title: Genome-wide association mapping and examination of possible maternal effect for the pace trait of horses.
  5. In the Icelandic horse breed, No DMRT3 SNP demonstrated genome-wide significance, implying that the ability to pace goes beyond the presence of a single gene variant.
    Title: To pace or not to pace: a pilot study of four- and five-gaited Icelandic horses homozygous for the DMRT3 'Gait Keeper' mutation.
  6. the spectrum of gait phenotypes strongly associated with the DMRT3 stop mutation is a recently derived trait
    Title: The evolutionary history of the DMRT3 'Gait keeper' haplotype.
  7. Previous studies have shown that a mutation from cytosine (C) to adenine (A) in the doublesex and mab-3 related transcription factor 3 (DMRT3) gene has a major impact on harness racing performance of different breeds. The current study provides no evidence to support such an association with DMRT3 in Coldblooded trotters.
    Title: Lack of significant associations with early career performance suggest no link between the DMRT3 "Gait Keeper" mutation and precocity in Coldblooded trotters.
  8. There was not a significant difference in the frequency of the DMRT3 mutation when comparing 5-gaited American Saddlebred horses to other American Saddlebred horses
    Title: Comparison of DMRT3 genotypes among American Saddlebred horses with reference to gait.
  9. This work finds a clear rationale for using the genotype at DMRT3 for multitrait evaluation.
    Title: Should we use the single nucleotide polymorphism linked to in genomic evaluation of French trotter?
  10. the DMRT3 mutation clearly influences gaits and performance in Finnhorses
    Title: Different DMRT3 Genotypes Are Best Adapted for Harness Racing and Riding in Finnhorses.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in male sex differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
doublesex and mab-3 related transcription factor 3
Names
Doublesex and mab-3 related transcription factor 3, truncated

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317265.1 → NP_001304194.1  doublesex and mab-3 related transcription factor 3

    Status: PROVISIONAL

    Source sequence(s)
    JQ922371
    UniProtKB/Swiss-Prot
    F6W2R2, J3SGP7
    Related
    ENSECAP00000020841.2, ENSECAT00000025062.2
    Conserved Domains (2) summary
    pfam00751
    Location:25 → 71
    DM; DM DNA binding domain
    cl21463
    Location:249 → 288
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_041296265.1-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference TB-T2T Primary Assembly

Genomic

  1. NC_091706.1 Reference TB-T2T Primary Assembly

    Range
    36112086..36126197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F6W2R2.2 GenPept UniProtKB/Swiss-Prot:F6W2R2
J7FCF0.1 GenPept UniProtKB/Swiss-Prot:J7FCF0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials