U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

srebf2 sterol regulatory element binding transcription factor 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100144677, updated on 6-Jul-2026
Official Symbol
srebf2provided by Xenbase
Official Full Name
sterol regulatory element binding transcription factor 2provided by Xenbase
Primary source
Xenbase:XB-GENE-1011360
See related
Ensembl:ENSXETG00000017449 AllianceGenome:Xenbase:XB-GENE-1011360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
srebp2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of cholesterol storage and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cholesterol metabolic process. Predicted to be located in ER to Golgi transport vesicle membrane; Golgi membrane; and endoplasmic reticulum membrane. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in carotid artery disease; diabetes mellitus (multiple); prostate cancer; sarcoma; and vascular dementia. Orthologous to human SREBF2 (sterol regulatory element binding transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See srebf2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
19
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (120125694..120164612)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (109736456..109774662)

Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene chromosome 4 C1orf21 homolog Neighboring gene coiled-coil domain containing 134 Neighboring gene microRNA mir-33b Neighboring gene uncharacterized LOC116410452 Neighboring gene cytochrome P450 2D6

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cholesterol storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
sterol regulatory element-binding protein 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123438.2 → NP_001116910.2  sterol regulatory element-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    BC161639, CT030351, CX901208, DT422965
    UniProtKB/TrEMBL
    A0A8J0QBD0, B1WB71
    Conserved Domains (1) summary
    cd18922
    Location:291 → 367
    bHLHzip_SREBP2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 2 (SREBP2) and similar proteins

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    120125694..120164612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012960582.3 → XP_012816036.1  sterol regulatory element-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    B1WB71, F6Z389
    Related
    ENSXETP00000037964.4, ENSXETT00000037964.5
    Conserved Domains (1) summary
    cd18922
    Location:293 → 369
    bHLHzip_SREBP2; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein 2 (SREBP2) and similar proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.