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NPG1 protegrin 1 [ Sus scrofa (pig) ]

Gene ID: 100144483, updated on 8-Apr-2026
Gene symbol
NPG1
Gene description
protegrin 1
See related
Ensembl:ENSSSCG00000053313 RGD:13920122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
NPG2; NPG5; PG-1; PG-2; PG-5
Expression
Biased expression in spleen (RPKM 14.3), lung (RPKM 4.9) and 3 other tissues See more
Try the new Gene page
Try the new Transcripts and proteins table
See NPG1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 13 NC_010455.5 (30986030..30987871)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 13 NC_010455.4 (34139006..34140850, complement)

Chromosome 13 - NC_010455.5Genomic Context describing neighboring genes Neighboring gene antibacterial protein Neighboring gene protegrin-3 Neighboring gene antibacterial peptide Neighboring gene antibacterial peptide PMAP-37

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Related articles in PubMed

  1. Transgenic Mice Overexpressing PG1 Display Corneal Opacity and Severe Inflammation in the Eye. Choi MK, et al. Int J Mol Sci, 2021 Feb 4. PMID 33557346, Free PMC Article
  2. Defining the genetic relationship of protegrin-related sequences and the in vivo expression of protegrins. Choi MK, et al. FEBS J, 2014 Dec. PMID 25264901
  3. Cysteine deleted protegrin-1 (CDP-1): anti-bacterial activity, outer-membrane disruption and selectivity. Mohanram H, et al. Biochim Biophys Acta, 2014 Oct. PMID 24997421
  4. Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes. Fahrner RL, et al. Chem Biol, 1996 Jul. PMID 8807886
  5. Synthesis and solution structure of the antimicrobial peptide protegrin-1. Aumelas A, et al. Eur J Biochem, 1996 May 1. PMID 8647100

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transgenic Mice Overexpressing PG1 Display Corneal Opacity and Severe Inflammation in the Eye.
    Title: Transgenic Mice Overexpressing PG1 Display Corneal Opacity and Severe Inflammation in the Eye.
  2. Further study suggested that protegrin-1 activates insulin-like growth factor 1 receptor (IGF1R) and through this receptor it modulates immune activity as well as cell migration.
    Title: Protegrin 1 Enhances Innate Cellular Defense via the Insulin-Like Growth Factor 1 Receptor Pathway.
  3. analyzed the expression pattern of protegrins in 17 different pig tissues using RT-PCR, and developed an anti-(PG-1) polyclonal IgG. Western blot analysis using the antibody showed that protegrins are mainly present as prepropeptide forms in normal tissue
    Title: Defining the genetic relationship of protegrin-related sequences and the in vivo expression of protegrins.
  4. Despite the absence of stabilizing disulfide bridges CDP-1 shows broad-spectrum antibacterial activity and assumes beta-hairpin like structure in complex with LPS.
    Title: Cysteine deleted protegrin-1 (CDP-1): anti-bacterial activity, outer-membrane disruption and selectivity.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
protegrin-1
Names
Protegrin-2
leukocyte antimicrobial peptide
neutrophil peptide 1
protegrin-3
protegrin-4
protegrin-5

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123149.2 → NP_001116621.2  protegrin-1 precursor

    Status: VALIDATED

    Source sequence(s)
    AEMK02000086
    UniProtKB/TrEMBL
    A0A4X1TPF0, A0A5G2QNY2
    Related
    ENSSSCP00000063793.2, ENSSSCT00000073391.2

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010455.5 Reference Sscrofa11.1 Primary Assembly

    Range
    30986030..30987871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32194.2 GenPept UniProtKB/Swiss-Prot:P32194
P32195.2 GenPept UniProtKB/Swiss-Prot:P32195
P49934.1 GenPept UniProtKB/Swiss-Prot:P49934

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials