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pkr3 double-stranded RNA activated protein kinase 3 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100141483, updated on 6-Jul-2026
Official Symbol
pkr3provided by Xenbase
Official Full Name
double-stranded RNA activated protein kinase 3provided by Xenbase
Primary source
Xenbase:XB-GENE-12565119
See related
Ensembl:ENSXETG00000009025 AllianceGenome:Xenbase:XB-GENE-12565119
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable ATP binding activity; RNA binding activity; and protein kinase activity. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; dystonia 33; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
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See pkr3 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
17
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 5 NC_030681.2 (41853890..41884521, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 5 NC_030681.1 (52024246..52048914, complement)

Chromosome 5 - NC_030681.2Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 2 Neighboring gene double-stranded RNA activated protein kinase 2 Neighboring gene alpha-tectorin Neighboring gene F-box protein 30

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications. Rothenburg S, et al. BMC Biol, 2008 Mar 3. PMID 18312693, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
interferon-induced, double-stranded RNA-activated protein kinase

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030681.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    41853890..41884521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031902508.1 → XP_031758368.1  interferon-induced, double-stranded RNA-activated protein kinase

    UniProtKB/TrEMBL
    F6ZVU2
    Related
    ENSXETP00000110867.1, ENSXETT00000112080.1
    Conserved Domains (3) summary
    cd10845
    Location:3 → 69
    DSRM_RNAse_III_family; double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins
    cl00054
    Location:117 → 183
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
    cl21453
    Location:257 → 523
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version

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