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AKT3 AKT serine/threonine kinase 3 [ Bos taurus (domestic cattle) ]

Gene ID: 100137872, updated on 30-Jan-2025
Official Symbol
AKT3provided by VGNC
Official Full Name
AKT serine/threonine kinase 3provided by VGNC
Primary source
VGNC:VGNC:25800
See related
BGD:BT10900; EnsemblRapid:ENSBTAG00070012321
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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See AKT3 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 16 NC_037343.1 (33357625..33638939)

Chromosome 16 - NC_037343.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger and BTB domain containing 18 Neighboring gene SHH signaling and ciliogenesis regulator SDCCAG8 Neighboring gene centrosomal protein 170 Neighboring gene programmed cell death protein 5-like

Genomic Sequence:
NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals. Farmanullah, et al. Biomed Res Int, 2020. PMID 32550227, Free PMC Article
  2. Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis. Ullah F, et al. Biomed Res Int, 2018. PMID 29862252, Free PMC Article
  3. The Wnt Signaling Pathway Is Differentially Expressed during the Bovine Herpesvirus 1 Latency-Reactivation Cycle: Evidence That Two Protein Kinases Associated with Neuronal Survival, Akt3 and BMPR2, Are Expressed at Higher Levels during Latency. Workman A, et al. J Virol, 2018 Apr 1. PMID 29321317, Free PMC Article
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals.
    Title: Adaptive Molecular Evolution of AKT3 Gene for Positive Diversifying Selection in Mammals.
  2. Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis.
    Title: Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis.
  3. These findings are important because Wnt, BMPR2, and Akt3 promote neurogenesis and cell survival, processes crucial for lifelong viral latency.
    Title: The Wnt Signaling Pathway Is Differentially Expressed during the Bovine Herpesvirus 1 Latency-Reactivation Cycle: Evidence That Two Protein Kinases Associated with Neuronal Survival, Akt3 and BMPR2, Are Expressed at Higher Levels during Latency.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
RAC-gamma serine/threonine-protein kinase
Names
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
NP_001178238.1
XP_024831735.1
XP_024831737.1
XP_024831739.1
XP_059731178.1
XP_059731179.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191309.1 → NP_001178238.1  RAC-gamma serine/threonine-protein kinase

    See identical proteins and their annotated locations for NP_001178238.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000016
    UniProtKB/TrEMBL
    A0AAA9SPW6
    Related
    ENSBTAP00070017032.1, ENSBTAT00070028023.1
    Conserved Domains (2) summary
    cd01241
    Location:4 → 110
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:132 → 479
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037343.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    33357625..33638939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024975971.2 → XP_024831739.1  RAC-gamma serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    A0AAA9SPW6
    Conserved Domains (2) summary
    cd05593
    Location:71 → 418
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    cl17171
    Location:1 → 49
    PH-like; Pleckstrin homology-like domain

  2. XM_059875195.1 → XP_059731178.1  RAC-gamma serine/threonine-protein kinase isoform X3

    UniProtKB/TrEMBL
    A0AAA9SPW6, A0AAA9TGK0
    Related
    ENSBTAP00070017082.1, ENSBTAT00070028075.1

  3. XM_024975967.2 → XP_024831735.1  RAC-gamma serine/threonine-protein kinase isoform X1

    UniProtKB/TrEMBL
    A0AAA9SPW6, A0AAA9T7A6
    Related
    ENSBTAP00070017100.1, ENSBTAT00070028093.1
    Conserved Domains (2) summary
    cd01241
    Location:3 → 97
    PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
    cd05593
    Location:119 → 466
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

  4. XM_024975969.2 → XP_024831737.1  RAC-gamma serine/threonine-protein kinase isoform X2

    UniProtKB/TrEMBL
    A0AAA9SPW6
    Conserved Domains (2) summary
    cd05593
    Location:71 → 418
    STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    cl17171
    Location:1 → 49
    PH-like; Pleckstrin homology-like domain

  5. XM_059875196.1 → XP_059731179.1  RAC-gamma serine/threonine-protein kinase isoform X4

    UniProtKB/TrEMBL
    A0AAA9RVP0, A0AAA9SPW6

RNA

  1. XR_009490745.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials