il6r interleukin 6 receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: il6rprovided by ZNC
Official Full Name: interleukin 6 receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-080107-7
See related: Ensembl:ENSDARG00000104474 AllianceGenome:ZFIN:ZDB-GENE-080107-7
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: il-6r; il-6ra
Summary: Predicted to enable cytokine binding activity and cytokine receptor activity. Acts upstream of or within positive regulation of neutrophil chemotaxis and wound healing. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including epidermis; immune system; lateral line; liver; and peripheral olfactory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	16	NC_133191.1 (23549041..23566247, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (22177254..22194400, complement)

Chromosome 16 - NC_133191.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

he secretion of IL6 mainly originates from HSC-independent myeloid cells, but not from HSCs and their adjacent vascular endothelial cells. In addition, blocking IL6 signaling does not affect vascular development or the production of primitive erythrocytes.
Title: Interleukin-6 signaling regulates hematopoietic stem cell emergence.
The expression of IL-6, IL-6R and gp130 transcripts were detected very early, increased during the first week of life and were predominantly expressed in the head, epidermis and neuromasts of the anterior and posterior lateral line system.
Title: Characterisation, expression and ontogeny of interleukin-6 and its receptors in zebrafish (Danio rerio).

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-6 receptor subunit alpha

Names: interleukin 6 receptor alpha; putative soluble interleukin-6 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001330258.2 → NP_001317187.2 interleukin-6 receptor subunit alpha precursor

Status: VALIDATED

Source sequence(s)

JBMGRA010000016

UniProtKB/TrEMBL

A0A8M1PAC4

Related

ENSDARP00000154692.1, ENSDART00000186042.1

Conserved Domains (1) summary

cd00063
Location:342 → 442

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

NC_133191.1 Reference GRCz12tu Primary Assembly

Range

23549041..23566247 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_073924435.1 → XP_073780536.1 interleukin-6 receptor subunit alpha isoform X2
XM_073924434.1 → XP_073780535.1 interleukin-6 receptor subunit alpha isoform X1

RNA

XR_012391292.1 RNA Sequence
XR_012391291.1 RNA Sequence
XR_012391290.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001114318.1: Suppressed sequence

Description

NM_001114318.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.