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Ptgr1 prostaglandin reductase 1 [ Cavia porcellus (domestic guinea pig) ]

Gene ID: 100135572, updated on 6-Sep-2025
Gene symbol
Ptgr1
Gene description
prostaglandin reductase 1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Cavia porcellus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
Also known as
DIG-1; Ltb4dh
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Ptgr1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947484.1 (177054362..177078700)
103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176326.1 (3649185..3672490, complement)

NW_026947484.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 10 Neighboring gene DnaJ heat shock protein family (Hsp40) member C25 Neighboring gene zinc finger protein 483 Neighboring gene uncharacterized LOC106026226

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop. Hori T, et al. J Biol Chem, 2004 May 21. PMID 15007077
  2. Immunohistochemical localization of guinea-pig leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase. Yamamoto T, et al. Eur J Biochem, 2001 Dec. PMID 11733004
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 15-oxoprostaglandin 13-reductase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 2-alkenal reductase [NAD(P)H] activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
prostaglandin reductase 1
Names
12-HD
15-oxoprostaglandin 13-reductase
D3T-inducible gene 1 protein
LTB4
NAD(P)H-dependent alkenal/one oxidoreductase
NADP-dependent leukotriene B4 12-hydroxydehydrogenase
PGR
PRG-1
dithiolethione-inducible gene 1 protein
leukotriene B4 12-hydroxydehydrogenase
leukotriene b4 12-hydroxydehydrogenase/prostaglandin 15-keto reductase
NP_001166451.1
XP_063103176.1
XP_063103661.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172980.1 → NP_001166451.1  prostaglandin reductase 1

    See identical proteins and their annotated locations for NP_001166451.1

    Status: PROVISIONAL

    Source sequence(s)
    AB021219
    UniProtKB/Swiss-Prot
    Q9EQZ5
    Conserved Domains (2) summary
    TIGR02825
    Location:4 → 327
    B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
    cd08294
    Location:2 → 329
    leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity

RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCavPor4.1

Genomic

  1. NW_026947484.1 Reference mCavPor4.1

    Range
    177054362..177078700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063247591.1 → XP_063103661.1  prostaglandin reductase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQZ5

  2. XM_063247106.1 → XP_063103176.1  prostaglandin reductase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQZ5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EQZ5.1 GenPept UniProtKB/Swiss-Prot:Q9EQZ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials