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Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 [ Cavia porcellus (domestic guinea pig) ]

Gene ID: 100135542, updated on 8-Mar-2024
Gene symbol
Hsd11b1
Gene description
hydroxysteroid 11-beta dehydrogenase 1
See related
Ensembl:ENSCPOG00000005596
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Cavia porcellus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae; Cavia
Orthologs
human mouse all
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See Hsd11b1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current mCavPor4.1 (GCF_034190915.1) Unplaced Scaffold NW_026947509.1 (18384926..18407269)
103 previous assembly Cavpor3.0 (GCF_000151735.1) Unplaced Scaffold NT_176406.1 (14259161..14281445)

NW_026947509.1Genomic Context describing neighboring genes Neighboring gene opsin 3 Neighboring gene kynurenine 3-monooxygenase Neighboring gene fumarate hydratase Neighboring gene TRAF3 interacting protein 3 Neighboring gene small ribosomal subunit protein eS27-like Neighboring gene chromosome unknown C1orf74 homolog

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions. Ogg D, et al. J Biol Chem, 2005 Feb 4. PMID 15542590
  2. Guinea pig 11beta-hydroxysteroid dehydrogenase type 1: primary structure and catalytic properties. Pu X, et al. Steroids, 2000 Mar. PMID 10699594
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 11-beta-hydroxysteroid dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in steroid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
11-beta-hydroxysteroid dehydrogenase 1
Names
11-DH
11-beta-HSD1
11-beta-hydroxysteroid dehydrogenase type 1
7-oxosteroid reductase
corticosteroid 11-beta-dehydrogenase isozyme 1
NP_001166328.1
XP_013012714.1
XP_063092684.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172857.1 → NP_001166328.1  11-beta-hydroxysteroid dehydrogenase 1

    See identical proteins and their annotated locations for NP_001166328.1

    Status: PROVISIONAL

    Source sequence(s)
    AF188005
    UniProtKB/Swiss-Prot
    Q6QLL4
    Related
    ENSCPOP00000005042.2, ENSCPOT00000005656.3
    Conserved Domains (2) summary
    cd05332
    Location:32 → 279
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    pfam00106
    Location:35 → 230
    adh_short; short chain dehydrogenase

RefSeqs of Annotated Genomes: GCF_034190915.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mCavPor4.1

Genomic

  1. NW_026947509.1 Reference mCavPor4.1

    Range
    18384926..18407269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_013157260.3 → XP_013012714.1  11-beta-hydroxysteroid dehydrogenase 1 isoform X1

    See identical proteins and their annotated locations for XP_013012714.1

    UniProtKB/Swiss-Prot
    Q6QLL4, Q9QZE1
    Conserved Domains (2) summary
    cd05332
    Location:32 → 279
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    pfam00106
    Location:35 → 230
    adh_short; short chain dehydrogenase

  2. XM_063236614.1 → XP_063092684.1  11-beta-hydroxysteroid dehydrogenase 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6QLL4.3 GenPept UniProtKB/Swiss-Prot:Q6QLL4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials