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hspb3 heat shock protein family B (small) member 3 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100135387, updated on 6-Jul-2026
Official Symbol
hspb3provided by Xenbase
Official Full Name
heat shock protein family B (small) member 3provided by Xenbase
Primary source
Xenbase:XB-GENE-969539
See related
AllianceGenome:Xenbase:XB-GENE-969539
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
hmn2c; dhmn2c; hspl27
Summary
Predicted to be active in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 4. Orthologous to human HSPB3 (heat shock protein family B (small) member 3). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See hspb3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
1
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (191979244..191980147, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (179117752..179118640, complement)

Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene chondroitin sulfate proteoglycan 4b Neighboring gene sorting nexin 18 Neighboring gene ARF like GTPase 15 Neighboring gene protein kinase C theta type-like Neighboring gene protein kinase C theta type-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by Xenbase

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
heat shock protein beta-3
Names
heat shock 27kDa protein 3

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    191979244..191980147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002941028.5 → XP_002941074.1  heat shock protein beta-3

    UniProtKB/TrEMBL
    A0A8J0QWZ6
    Conserved Domains (1) summary
    cl00175
    Location:55 → 137
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials