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il7r interleukin 7 receptor [ Danio rerio (zebrafish) ]

Gene ID: 100134973, updated on 9-Sep-2025
Official Symbol
il7rprovided by ZNC
Official Full Name
interleukin 7 receptorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080110-7
See related
Ensembl:ENSDARG00000078970 AllianceGenome:ZFIN:ZDB-GENE-080110-7
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
il-7ra
Summary
Predicted to enable cytokine receptor activity. Acts upstream of or within several processes, including myelination; positive regulation of receptor signaling pathway via JAK-STAT; and thymus development. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in T cell; brain; lymphoid progenitor cell; and thymus. Human ortholog(s) of this gene implicated in colon cancer; lung non-small cell carcinoma; primary immunodeficiency disease; severe combined immunodeficiency; and stomach cancer. Orthologous to human IL7R (interleukin 7 receptor). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See il7r in Genome Data Viewer
Location:
chromosome: 21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 21 NC_133196.1 (23888287..23896083, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 21 NC_007132.7 (22428308..22436005, complement)

Chromosome 21 - NC_133196.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141379863 Neighboring gene uncharacterized LOC137488810 Neighboring gene U6 spliceosomal RNA Neighboring gene si:ch73-112l6.1 Neighboring gene LMBR1 domain containing 2b Neighboring gene calcyphosine-like b Neighboring gene myosin VB Neighboring gene cilia and flagella associated protein 53

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Single-cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver. Morrison JK, et al. Hepatol Commun, 2022 Jul. PMID 35315595, Free PMC Article
  2. Genetic evidence for an evolutionarily conserved role of IL-7 signaling in T cell development of zebrafish. Iwanami N, et al. J Immunol, 2011 Jun 15. PMID 21562163
  3. Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis. Boopathy GTK, et al. J Biol Chem, 2017 Oct 27. PMID 28912276, Free PMC Article
  4. Foxn1 is not essential for T-cell development in teleosts. Schorpp M, et al. Eur J Immunol, 2023 Dec. PMID 37724048
  5. T Cell Immune Deficiency in zap70 Mutant Zebrafish. Moore JC, et al. Mol Cell Biol, 2016 Dec 1. PMID 27601584, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia.
    Title: Mutant IL7R collaborates with MYC to induce T-cell acute lymphoblastic leukemia.
  2. Il7r is an essential molecule for maintaining normal retinal development in zebrafish.
    Title: Knockout of zebrafish interleukin 7 receptor (IL7R) by the CRISPR/Cas9 system delays retinal neurodevelopment.
  3. A presumptive null allele of the zebrafish homolog of the IL-7Ralpha-chain causes substantially reduced cellularity of the thymus
    Title: Genetic evidence for an evolutionarily conserved role of IL-7 signaling in T cell development of zebrafish.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-7 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in T cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within central nervous system myelination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemopoiesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-7-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural retina development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within visual behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
interleukin-7 receptor subunit alpha
Names
interleukin 7 receptor alpha

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113507.2 → NP_001106979.2  interleukin-7 receptor subunit alpha precursor

    Status: VALIDATED

    Source sequence(s)
    BN000775, CN018734, JBMGRA010000021
    UniProtKB/TrEMBL
    A0A8M1NFN7, E9QDP8, F1Q7Z1
    Related
    ENSDARP00000119705.2, ENSDART00000137959.3

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133196.1 Reference GRCz12tu Primary Assembly

    Range
    23888287..23896083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073934201.1 → XP_073790302.1  interleukin-7 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0AB32TBE4

  2. XM_073934198.1 → XP_073790299.1  interleukin-7 receptor subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M1NFN7, E9QDP8, F1Q7Z1

  3. XM_073934202.1 → XP_073790303.1  interleukin-7 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0AB32TBE4

  4. XM_073934203.1 → XP_073790304.1  interleukin-7 receptor subunit alpha isoform X3

    UniProtKB/TrEMBL
    A8WH87

  5. XM_073934200.1 → XP_073790301.1  interleukin-7 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0AB32TBE4

  6. XM_068215755.2 → XP_068071856.1  interleukin-7 receptor subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M1NFN7, E9QDP8, F1Q7Z1

  7. XM_073934199.1 → XP_073790300.1  interleukin-7 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0AB32TBE4

  8. XM_068215756.2 → XP_068071857.1  interleukin-7 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0AB32TBE4
Nucleotide Protein Strain
Heading Accession and Version

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