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FILNC1 FOXO induced long non-coding RNA 1 [ Homo sapiens (human) ]

Gene ID: 100132735, updated on 13-May-2022

Summary

Official Symbol
FILNC1provided by HGNC
Official Full Name
FOXO induced long non-coding RNA 1provided by HGNC
Primary source
HGNC:HGNC:53755
See related
Ensembl:ENSG00000231426 AllianceGenome:HGNC:53755
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene produces a long non-coding RNA that is induced by forkhead box O proteins and plays a role in stress-induced apoptosis. Knock down of transcripts at this locus results in increased renal tumor growth and alteration in genes involved in glucose metabolism. This RNA interacts with heterogeneous nuclear ribonucleoprotein D and prevents it from binding to Myc mRNA, therefore suppressing Myc activity. Alternative splicing and transcriptional start site usage results in multiple transcript variants. [provided by RefSeq, Oct 2017]
Expression
Low expression observed in reference dataset See more
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Genomic context

See FILNC1 in Genome Data Viewer
Location:
6q24.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (139771073..139860471)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (140954833..141044210)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (140092210..140181608)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr6.4973 Neighboring gene thyroid hormone receptor interactor 4 pseudogene Neighboring gene VISTA enhancer hs1644 Neighboring gene Sharpr-MPRA regulatory region 3903

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

General gene information

Markers

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_038399.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL050338, BM905115
    Related
    ENST00000647420.1
  2. NR_138541.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL050338, BM788274
  3. NR_138542.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AA058905, AL050338, BM788274

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    139771073..139860471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    140954833..141044210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)