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CLDN24 claudin 24 [ Homo sapiens (human) ]

Gene ID: 100132463, updated on 22-Sep-2022

Summary

Official Symbol
CLDN24provided by HGNC
Official Full Name
claudin 24provided by HGNC
Primary source
HGNC:HGNC:37200
See related
Ensembl:ENSG00000185758 AllianceGenome:HGNC:37200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLDN21
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is 75% identical to the mouse homolog. This gene is upstream of the CLDN22 gene, which overlaps the WWC2 gene on the opposite strand in the genome.[provided by RefSeq, Aug 2010]
Orthologs
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Genomic context

See CLDN24 in Genome Data Viewer
Location:
4q35.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (183321764..183322426, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (186665220..186665882, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (184242917..184243579, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene WW and C2 domain containing 2 Neighboring gene small nucleolar RNA U13 Neighboring gene small nucleolar RNA U13 Neighboring gene claudin 22 Neighboring gene chimerin 1 pseudogene

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative claudin-24
Names
claudin 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185149.1NP_001172078.1  putative claudin-24

    See identical proteins and their annotated locations for NP_001172078.1

    Status: VALIDATED

    Source sequence(s)
    AC093844
    Consensus CDS
    CCDS54824.1
    UniProtKB/Swiss-Prot
    A6NM45, F5H040
    Related
    ENSP00000438400.1, ENST00000541814.1
    Conserved Domains (1) summary
    cl21598
    Location:49172
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    183321764..183322426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    186665220..186665882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)