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ZNF717 zinc finger protein 717 [ Homo sapiens (human) ]

Gene ID: 100131827, updated on 13-Mar-2020

Summary

Official Symbol
ZNF717provided by HGNC
Official Full Name
zinc finger protein 717provided by HGNC
Primary source
HGNC:HGNC:29448
See related
Ensembl:ENSG00000227124 MIM:618405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OB1; X17; ZNF838
Summary
This gene encodes a Kruppel-associated box (KRAB) zinc-finger protein, which belongs to a large group of transcriptional regulators in mammals. These proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation and apoptosis, and in regulating viral replication and transcription. A pseudogene of this gene was identified on chromosome 1. [provided by RefSeq, May 2016]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in testis (RPKM 1.7), thyroid (RPKM 1.6) and 25 other tissues See more
Orthologs

Genomic context

See ZNF717 in Genome Data Viewer
Location:
3p12.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (75729961..75785578, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (75785868..75834709, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 960 Neighboring gene RNA, 7SL, cytoplasmic 92, pseudogene Neighboring gene microRNA 4273 Neighboring gene roundabout guidance receptor 2 Neighboring gene uncharacterized LOC107986020 Neighboring gene CAP1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41782

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 717
Names
krueppel-like factor X17
kruppel-like zinc finger factor X17
zinc finger protein 838

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047070.1 RefSeqGene

    Range
    5035..54716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128223.3NP_001121695.1  zinc finger protein 717 isoform a

    See identical proteins and their annotated locations for NP_001121695.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC108724, DB079386, DB491038, DR006008
    Conserved Domains (6) summary
    smart00349
    Location:2282
    KRAB; krueppel associated box
    COG5048
    Location:309689
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:816836
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:870892
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2261
    KRAB; KRAB box
    pfam13465
    Location:465490
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001290208.3NP_001277137.1  zinc finger protein 717 isoform a

    See identical proteins and their annotated locations for NP_001277137.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC108724, DA618280, DB079386, DR006008, HY057162
    Related
    ENSP00000498738.1, ENST00000652011.2
    Conserved Domains (6) summary
    smart00349
    Location:2282
    KRAB; krueppel associated box
    COG5048
    Location:309689
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:816836
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:870892
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2261
    KRAB; KRAB box
    pfam13465
    Location:465490
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001290209.3NP_001277138.1  zinc finger protein 717 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC108724, DA618280, DB079386, DR006008
    Consensus CDS
    CCDS77773.1
    UniProtKB/TrEMBL
    C9JVC3
    Related
    ENSP00000419377.1, ENST00000478296.5
    Conserved Domains (5) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:259639
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:766786
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:820842
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:415440
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001290210.2NP_001277139.1  zinc finger protein 717 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, and contains alternate 3' exon structure and it thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a. Variants 4 and 5 encode the same isoform.
    Source sequence(s)
    BQ189284, BQ928230, BX091527, DA618280, DR006008
    Consensus CDS
    CCDS77774.1
    UniProtKB/TrEMBL
    C9J5W8
    Related
    ENSP00000417902.1, ENST00000477374.5
    Conserved Domains (2) summary
    smart00349
    Location:2282
    KRAB; krueppel associated box
    pfam01352
    Location:2261
    KRAB; KRAB box
  5. NM_001324026.2NP_001310955.1  zinc finger protein 717 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: Variants 4 and 5 encode the same isoform (c).
    Source sequence(s)
    AC108724, AC133123, BQ189284
    Consensus CDS
    CCDS77774.1
    UniProtKB/TrEMBL
    C9J5W8
    Conserved Domains (2) summary
    smart00349
    Location:2282
    KRAB; krueppel associated box
    pfam01352
    Location:2261
    KRAB; KRAB box
  6. NM_001324027.1NP_001310956.1  zinc finger protein 717 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC108724, AC133123, BQ189284
  7. NM_001324028.1NP_001310957.1  zinc finger protein 717 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC108724, AC133123, BQ189284

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    75729961..75785578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453285.1XP_024309053.1  zinc finger protein 717 isoform X9

    Conserved Domains (1) summary
    smart00349
    Location:1575
    KRAB; krueppel associated box
  2. XM_011533246.3XP_011531548.1  zinc finger protein 717 isoform X3

    Conserved Domains (5) summary
    smart00349
    Location:56116
    KRAB; krueppel associated box
    COG5048
    Location:343723
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:543563
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5695
    KRAB; KRAB box
    pfam13465
    Location:499524
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011533248.2XP_011531550.1  zinc finger protein 717 isoform X6

    Conserved Domains (6) summary
    smart00349
    Location:56116
    KRAB; krueppel associated box
    COG5048
    Location:343723
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:543563
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:429451
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:5695
    KRAB; KRAB box
    pfam13465
    Location:499524
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011533249.3XP_011531551.1  zinc finger protein 717 isoform X7

    Conserved Domains (5) summary
    smart00349
    Location:56116
    KRAB; krueppel associated box
    COG5048
    Location:343723
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:543563
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:5695
    KRAB; KRAB box
    pfam13465
    Location:499524
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011533250.3XP_011531552.1  zinc finger protein 717 isoform X8

    Conserved Domains (2) summary
    smart00349
    Location:56116
    KRAB; krueppel associated box
    pfam01352
    Location:5695
    KRAB; KRAB box
  6. XM_011533251.2XP_011531553.1  zinc finger protein 717 isoform X10

    Conserved Domains (2) summary
    smart00349
    Location:56116
    KRAB; krueppel associated box
    pfam01352
    Location:5695
    KRAB; KRAB box
  7. XM_005264711.4XP_005264768.1  zinc finger protein 717 isoform X4

    See identical proteins and their annotated locations for XP_005264768.1

    Conserved Domains (6) summary
    smart00349
    Location:2282
    KRAB; krueppel associated box
    COG5048
    Location:309689
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:816836
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:870892
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2261
    KRAB; KRAB box
    pfam13465
    Location:465490
    zf-H2C2_2; Zinc-finger double domain
  8. XM_011533245.3XP_011531547.1  zinc finger protein 717 isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:3494
    KRAB; krueppel associated box
    COG5048
    Location:321701
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:828848
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:882904
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3473
    KRAB; KRAB box
    pfam13465
    Location:477502
    zf-H2C2_2; Zinc-finger double domain
  9. XM_024453284.1XP_024309052.1  zinc finger protein 717 isoform X5

    Conserved Domains (3) summary
    smart00349
    Location:1575
    KRAB; krueppel associated box
    COG5048
    Location:302682
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:809829
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. XM_011533244.3XP_011531546.1  zinc finger protein 717 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:56116
    KRAB; krueppel associated box
    COG5048
    Location:343723
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:850870
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:904926
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:5695
    KRAB; KRAB box
    pfam13465
    Location:499524
    zf-H2C2_2; Zinc-finger double domain
  11. XM_006712912.4XP_006712975.1  zinc finger protein 717 isoform X5

    Conserved Domains (3) summary
    smart00349
    Location:1575
    KRAB; krueppel associated box
    COG5048
    Location:302682
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:809829
    ZF_C2H2; C2H2 Zn finger [structural motif]
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