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ARMCX4 armadillo repeat containing X-linked 4 [ Homo sapiens (human) ]

Gene ID: 100131755, updated on 1-Aug-2020

Summary

Official Symbol
ARMCX4provided by HGNC
Official Full Name
armadillo repeat containing X-linked 4provided by HGNC
Primary source
HGNC:HGNC:28615
See related
Ensembl:ENSG00000196440 MIM:301046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GASP4; CXorf35
Summary
The product of this gene belongs to the armadillo repeat-containing family of proteins, which interact with other proteins in a variety of cellular processes. The function of this family member is currently unknown. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in ovary (RPKM 3.6), brain (RPKM 2.9) and 24 other tissues See more
Orthologs

Genomic context

See ARMCX4 in Genome Data Viewer
Location:
Xq22.1
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (101418278..101535988)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (100673064..100790975)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RPL36A-HNRNPH2 readthrough Neighboring gene heterogeneous nuclear ribonucleoprotein H2 Neighboring gene galactosidase alpha Neighboring gene peptidylprolyl isomerase A pseudogene 90 Neighboring gene PRKCI pseudogene 1 Neighboring gene armadillo repeat containing X-linked 1 Neighboring gene armadillo repeat containing X-linked 7, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ARMCX1

Homology

Clone Names

  • FLJ39636, FLJ43051, FLJ45041, MGC40053, DKFZp586N0819, DKFZp781M0415

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
armadillo repeat-containing X-linked protein 4
Names
armadillo repeat containing, X-linked 4 pseudogene

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017196.3 RefSeqGene

    Range
    74767..82534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256155.2NP_001243084.2  armadillo repeat-containing X-linked protein 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents a protein-coding variant and contains a long, terminal coding exon instead of extensive splicing found in variant 2. The full extent of the 5' UTR has not been determined.
    Source sequence(s)
    KF459252, Z68873
    Consensus CDS
    CCDS59170.1
    UniProtKB/TrEMBL
    F8W8Y7
    Related
    ENSP00000404304.3, ENST00000423738.4
    Conserved Domains (3) summary
    PRK07735
    Location:84320
    PRK07735; NADH dehydrogenase subunit C; Validated
    pfam04826
    Location:20322283
    Arm_2; Armadillo-like
    sd00043
    Location:20762110
    ARM; armadillo repeat [structural motif]

RNA

  1. NR_028407.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. This variant is represented as non-coding because use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC234775, AL035422, Z68873
  2. NR_045861.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and has multiple splicing differences, compared to variant 2. This variant is represented as non-coding because use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC234775, Z68873
  3. NR_045862.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter and has multiple splicing differences, compared to variant 2. This variant is represented as non-coding because it lacks all of the coding region found in variant 1.
    Source sequence(s)
    AC234775, Z68873
  4. NR_045863.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and has multiple splicing differences, compared to variant 2. This variant is represented as non-coding because it lacks all of the coding region found in variant 1.
    Source sequence(s)
    Z68873
    Related
    ENST00000445416.5
  5. NR_045864.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and has multiple splicing differences, compared to variant 2. This variant is represented as non-coding because use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC234775, Z68873

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    101418278..101535988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152583.2: Suppressed sequence

    Description
    NM_152583.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
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