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NEMP2 nuclear envelope integral membrane protein 2 [ Homo sapiens (human) ]

Gene ID: 100131211, updated on 25-Jan-2022

Summary

Official Symbol
NEMP2provided by HGNC
Official Full Name
nuclear envelope integral membrane protein 2provided by HGNC
Primary source
HGNC:HGNC:33700
See related
Ensembl:ENSG00000189362 MIM:616497; AllianceGenome:HGNC:33700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM194B
Summary
Predicted to be located in nuclear inner membrane. Predicted to be integral component of membrane. Predicted to be active in nuclear envelope. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in testis (RPKM 2.0), lymph node (RPKM 1.7) and 25 other tissues See more
Orthologs
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Genomic context

See NEMP2 in Genome Data Viewer
Location:
2q32.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (190454088..190607126, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (191369064..191399448, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-1-phosphatase Neighboring gene uncharacterized LOC105373802 Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene NEMP2 divergent transcript Neighboring gene RN7SK pseudogene 179 Neighboring gene NGFI-A binding protein 1 Neighboring gene CRISPRi-validated cis-regulatory element chr2.5899

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear envelope integral membrane protein 2
Names
UPF0571 transmembrane protein
transmembrane protein 194B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142645.2NP_001136117.1  nuclear envelope integral membrane protein 2 precursor

    See identical proteins and their annotated locations for NP_001136117.1

    Status: VALIDATED

    Source sequence(s)
    AC093388
    Consensus CDS
    CCDS46476.1
    UniProtKB/Swiss-Prot
    A6NFY4
    Related
    ENSP00000386292.3, ENST00000409150.8
    Conserved Domains (1) summary
    pfam10225
    Location:143390
    DUF2215; Uncharacterized conserved protein (DUF2215)

RNA

  1. NR_136298.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA521390, AC093388, AK296987, AK302425, DA417772

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    190454088..190607126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003100.1XP_016858589.1  nuclear envelope integral membrane protein 2 isoform X3

  2. XM_011510458.3XP_011508760.1  nuclear envelope integral membrane protein 2 isoform X4

    Conserved Domains (1) summary
    pfam10225
    Location:143376
    DUF2215; Uncharacterized conserved protein (DUF2215)
  3. XM_024452364.1XP_024308132.1  nuclear envelope integral membrane protein 2 isoform X6

    Conserved Domains (1) summary
    pfam10225
    Location:74307
    NEMP; NEMP family
  4. XM_017003099.1XP_016858588.1  nuclear envelope integral membrane protein 2 isoform X2

  5. XM_017003098.1XP_016858587.1  nuclear envelope integral membrane protein 2 isoform X1

  6. XM_005246213.3XP_005246270.1  nuclear envelope integral membrane protein 2 isoform X7

    Conserved Domains (1) summary
    pfam10225
    Location:2249
    DUF2215; Uncharacterized conserved protein (DUF2215)
  7. XM_005246212.3XP_005246269.1  nuclear envelope integral membrane protein 2 isoform X5

    See identical proteins and their annotated locations for XP_005246269.1

    Conserved Domains (1) summary
    pfam10225
    Location:74321
    DUF2215; Uncharacterized conserved protein (DUF2215)
  8. XM_011510459.3XP_011508761.1  nuclear envelope integral membrane protein 2 isoform X5

    See identical proteins and their annotated locations for XP_011508761.1

    Conserved Domains (1) summary
    pfam10225
    Location:74321
    DUF2215; Uncharacterized conserved protein (DUF2215)
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