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LRRC70 leucine rich repeat containing 70 [ Homo sapiens (human) ]

Gene ID: 100130733, updated on 10-Dec-2019

Summary

Official Symbol
LRRC70provided by HGNC
Official Full Name
leucine rich repeat containing 70provided by HGNC
Primary source
HGNC:HGNC:35155
See related
Ensembl:ENSG00000186105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLRN
Expression
Ubiquitous expression in fat (RPKM 4.2), thyroid (RPKM 3.6) and 22 other tissues See more
Orthologs

Genomic context

See LRRC70 in Genome Data Viewer
Location:
5q12.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (62578819..62581446)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (61874562..61877275)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene importin 11 Neighboring gene CDC28 protein kinase regulatory subunit 1B pseudogene 3 Neighboring gene IPO11-LRRC70 readthrough Neighboring gene ribosomal protein L35a pseudogene 14 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 1 Neighboring gene dedicator of cytokinesis 9 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough IPO11-LRRC70

Readthrough gene: IPO11-LRRC70, Included gene: IPO11

Homology

Clone Names

  • FLJ41026, DKFZp686E10165

Gene Ontology Provided by GOA

Process Evidence Code Pubs
positive regulation of response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat-containing protein 70
Names
synleurin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181506.5NP_852607.3  leucine-rich repeat-containing protein 70 precursor

    See identical proteins and their annotated locations for NP_852607.3

    Status: VALIDATED

    Source sequence(s)
    AK123022, BC110838
    Consensus CDS
    CCDS47218.1
    UniProtKB/Swiss-Prot
    Q7Z2Q7
    Related
    ENSP00000399441.1, ENST00000334994.6
    Conserved Domains (5) summary
    smart00013
    Location:3162
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:359398
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:159340
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:110133
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:133192
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    62578819..62581446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_009724.1: Suppressed sequence

    Description
    NG_009724.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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