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TMEM221 transmembrane protein 221 [ Homo sapiens (human) ]

Gene ID: 100130519, updated on 5-Jul-2025
Official Symbol
TMEM221provided by HGNC
Official Full Name
transmembrane protein 221provided by HGNC
Primary source
HGNC:HGNC:21943
See related
Ensembl:ENSG00000188051 AllianceGenome:HGNC:21943
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Jiraiya
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Broad expression in ovary (RPKM 1.6), adrenal (RPKM 1.1) and 16 other tissues See more
Orthologs
mouse all
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See TMEM221 in Genome Data Viewer
Location:
19p13.11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (17435509..17448668, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (17570277..17583426, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17546318..17559477, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17518151-17518677 Neighboring gene multivesicular body subunit 12A Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:17525723-17526510 Neighboring gene BST2 interferon stimulated positive regulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10343 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10344 Neighboring gene high mobility group box 3 pseudogene 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17534662-17535187 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17571641-17572141 Neighboring gene nucleoredoxin like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17581949-17582450 Neighboring gene Sharpr-MPRA regulatory region 2801 Neighboring gene solute carrier family 27 member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:17593839-17594340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14275 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:17599959-17600122 Neighboring gene PGLS divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17609403-17609947 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17610300-17611168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:17611169-17612037

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Jiraiya attenuates BMP signaling by interfering with type II BMP receptors in neuroectodermal patterning. Aramaki T, et al. Dev Cell, 2010 Oct 19. PMID 20951346
  2. Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. Choy KW, et al. Physiol Genomics, 2006 Mar 13. PMID 16368877
  3. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824
  4. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Stukalov A, et al. Nature, 2021 Jun. PMID 33845483
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
transmembrane protein 221
Names
Putative transmembrane protein ENSP00000342162

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190844.2 → NP_001177773.1  transmembrane protein 221

    See identical proteins and their annotated locations for NP_001177773.1

    Status: VALIDATED

    Source sequence(s)
    AC010319, BY797043
    Consensus CDS
    CCDS54230.1
    UniProtKB/Swiss-Prot
    A6NGB7
    Related
    ENSP00000342162.5, ENST00000341130.6
    Conserved Domains (1) summary
    pfam15038
    Location:32 → 186
    Jiraiya; Jiraiya

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    17435509..17448668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527603.3 → XP_011525905.1  transmembrane protein 221 isoform X1

    See identical proteins and their annotated locations for XP_011525905.1

    Conserved Domains (1) summary
    pfam15038
    Location:32 → 186
    Jiraiya; Jiraiya

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    17570277..17583426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319457.1 → XP_054175432.1  transmembrane protein 221 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NGB7.3 GenPept UniProtKB/Swiss-Prot:A6NGB7

Gene LinkOut

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