WAKMAR2 wound and keratinocyte migration associated lncRNA 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: WAKMAR2provided by HGNC
Official Full Name: wound and keratinocyte migration associated lncRNA 2provided by HGNC
Primary source: HGNC:HGNC:53754
See related: Ensembl:ENSG00000237499 MIM:618508; AllianceGenome:HGNC:53754
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: lnc-TNFAIP3
Expression: Broad expression in skin (RPKM 4.7), bone marrow (RPKM 3.3) and 16 other tissues See more
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Genomic context

Location:: 6q23.3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (137823669..137868233, complement)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (139012092..139056654, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (138144806..138189370, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA-WAKMAR2 regulates expression of CLDN1 to affect skin barrier through recruiting c-Fos.
Title: LncRNA-WAKMAR2 regulates expression of CLDN1 to affect skin barrier through recruiting c-Fos.
Study data suggest that WAKMAR2 is an important regulator of skin wound healing through production of inflammatory chemokines by keratinocytes, and cell migration enhancing and its deficiency may contribute to the pathogenesis of chronic wounds.
Title: WAKMAR2, a Long Noncoding RNA Downregulated in Human Chronic Wounds, Modulates Keratinocyte Motility and Production of Inflammatory Chemokines.
aberrant methylation of LOC100130476 in peripheral white blood cells andgastric cardia adenocarcinoma ( GCA) tissues may be used as a potential valuable biomarker in GCA diagnosis and prognosis
Title: Methylation-mediated downregulation of long noncoding RNA LOC100130476 in gastric cardia adenocarcinoma.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

PMC355833P1 (e-PCR)
- UniSTS:273253

PMC355833P2 (e-PCR)
- UniSTS:273254

PMC135646P1 (e-PCR)
- UniSTS:270765

PMC135646P2 (e-PCR)
- UniSTS:270766

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.