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HSFX2 heat shock transcription factor family, X-linked 2 [ Homo sapiens (human) ]

Gene ID: 100130086, updated on 13-May-2022

Summary

Official Symbol
HSFX2provided by HGNC
Official Full Name
heat shock transcription factor family, X-linked 2provided by HGNC
Primary source
HGNC:HGNC:32701
See related
Ensembl:ENSG00000268738 AllianceGenome:HGNC:32701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 4.0), ovary (RPKM 1.8) and 22 other tissues See more
Orthologs
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Genomic context

See HSFX2 in Genome Data Viewer
Location:
Xq28
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (149592512..149595314, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (147858263..147861065, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (148674172..148676974, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene endothelium and lymphocyte associated ASCH domain 1 Neighboring gene heat shock transcription factor family, X-linked member 3 Neighboring gene MAGE family member A9B Neighboring gene transmembrane protein 185A Neighboring gene FRAXF repeat instability region Neighboring gene MAGE family member A11 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ17347, MGC26102

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
heat shock transcription factor, X-linked

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164415.3NP_001157887.1  heat shock transcription factor, X-linked

    See identical proteins and their annotated locations for NP_001157887.1

    Status: VALIDATED

    Source sequence(s)
    AC244197, BC021706
    Consensus CDS
    CCDS48179.1
    UniProtKB/Swiss-Prot
    Q9UBD0
    UniProtKB/TrEMBL
    A0A140VK21
    Related
    ENSP00000469223.1, ENST00000598963.3
    Conserved Domains (1) summary
    pfam00447
    Location:105211
    HSF_DNA-bind; HSF-type DNA-binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    149592512..149595314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    147858263..147861065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)