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ZNF730 zinc finger protein 730 [ Homo sapiens (human) ]

Gene ID: 100129543, updated on 8-Feb-2025

Summary

Official Symbol
ZNF730provided by HGNC
Official Full Name
zinc finger protein 730provided by HGNC
Primary source
HGNC:HGNC:32470
See related
Ensembl:ENSG00000183850 AllianceGenome:HGNC:32470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Feb 2025]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ZNF730 in Genome Data Viewer
Location:
19p12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23075211..23147221)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (23210338..23282034)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23299827..23330023)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1859 Neighboring gene long intergenic non-protein coding RNA 1858 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23257625-23258372 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:23260515-23261088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:23276545-23277044 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene BCL2 interacting protein 3 pseudogene 37 Neighboring gene sorting nexin 6 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:23343199-23343774 Neighboring gene MPRA-validated peak3415 silencer Neighboring gene zinc finger protein 724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14391 Neighboring gene BCL2 interacting protein 3 pseudogene 38 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10460 Neighboring gene importin 5 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative zinc finger protein 730

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277403.2NP_001264332.1  putative zinc finger protein 730

    See identical proteins and their annotated locations for NP_001264332.1

    Status: VALIDATED

    Source sequence(s)
    AC092329, AK131472
    Consensus CDS
    CCDS59371.1
    UniProtKB/Swiss-Prot
    Q6ZMV8
    Related
    ENSP00000472959.1, ENST00000597761.7
    Conserved Domains (5) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:143498
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:398418
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:270295
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    23075211..23147221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437995.1XP_047293951.1  putative zinc finger protein 730 isoform X4

  2. XM_047437996.1XP_047293952.1  putative zinc finger protein 730 isoform X4

  3. XM_047437997.1XP_047293953.1  putative zinc finger protein 730 isoform X4

  4. XM_047437999.1XP_047293955.1  putative zinc finger protein 730 isoform X4

  5. XM_047437998.1XP_047293954.1  putative zinc finger protein 730 isoform X4

  6. XM_017026115.3XP_016881604.1  putative zinc finger protein 730 isoform X2

  7. XM_047438000.1XP_047293956.1  putative zinc finger protein 730 isoform X4

  8. XM_047437994.1XP_047293950.1  putative zinc finger protein 730 isoform X4

  9. XM_047438004.1XP_047293960.1  putative zinc finger protein 730 isoform X4

  10. XM_047438001.1XP_047293957.1  putative zinc finger protein 730 isoform X4

  11. XM_017026114.2XP_016881603.1  putative zinc finger protein 730 isoform X1

  12. XM_047438005.1XP_047293961.1  putative zinc finger protein 730 isoform X6

    UniProtKB/TrEMBL
    Q75LP1
  13. XM_047437993.1XP_047293949.1  putative zinc finger protein 730 isoform X3

  14. XM_047438002.1XP_047293958.1  putative zinc finger protein 730 isoform X5

  15. XM_047438003.1XP_047293959.1  putative zinc finger protein 730 isoform X5

RNA

  1. XR_001753564.2 RNA Sequence

  2. XR_001753566.3 RNA Sequence

  3. XR_001753565.2 RNA Sequence

  4. XR_001753568.2 RNA Sequence

  5. XR_007066501.1 RNA Sequence

  6. XR_001753567.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    23210338..23282034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319432.1XP_054175407.1  putative zinc finger protein 730 isoform X2

  2. XM_054319434.1XP_054175409.1  putative zinc finger protein 730 isoform X7

  3. XM_054319438.1XP_054175413.1  putative zinc finger protein 730 isoform X7

  4. XM_054319441.1XP_054175416.1  putative zinc finger protein 730 isoform X4

  5. XM_054319436.1XP_054175411.1  putative zinc finger protein 730 isoform X7

  6. XM_054319442.1XP_054175417.1  putative zinc finger protein 730 isoform X4

  7. XM_054319437.1XP_054175412.1  putative zinc finger protein 730 isoform X7

  8. XM_054319440.1XP_054175415.1  putative zinc finger protein 730 isoform X7

  9. XM_054319439.1XP_054175414.1  putative zinc finger protein 730 isoform X7

  10. XM_054319443.1XP_054175418.1  putative zinc finger protein 730 isoform X4

  11. XM_054319435.1XP_054175410.1  putative zinc finger protein 730 isoform X7

  12. XM_054319447.1XP_054175422.1  putative zinc finger protein 730 isoform X4

  13. XM_054319444.1XP_054175419.1  putative zinc finger protein 730 isoform X4

  14. XM_054319431.1XP_054175406.1  putative zinc finger protein 730 isoform X1

  15. XM_054319448.1XP_054175423.1  putative zinc finger protein 730 isoform X6

    UniProtKB/TrEMBL
    Q75LP1
  16. XM_054319433.1XP_054175408.1  putative zinc finger protein 730 isoform X3

  17. XM_054319445.1XP_054175420.1  putative zinc finger protein 730 isoform X5

  18. XM_054319446.1XP_054175421.1  putative zinc finger protein 730 isoform X5