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TDRD15 tudor domain containing 15 [ Homo sapiens (human) ]

Gene ID: 100129278, updated on 10-Dec-2024

Summary

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Official Symbol
TDRD15provided by HGNC
Official Full Name
tudor domain containing 15provided by HGNC
Primary source
HGNC:HGNC:45037
See related
Ensembl:ENSG00000218819 AllianceGenome:HGNC:45037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 3.5) See more
Orthologs
all
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Genomic context

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See TDRD15 in Genome Data Viewer
Location:
2p24.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (21123932..21147325)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (21157138..21180528)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (21346840..21367240)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene APOB 3' scaffold/matrix attachment region Neighboring gene apolipoprotein B Neighboring gene APOB 5' regulatory region Neighboring gene Sharpr-MPRA regulatory region 5245 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:21290821-21291609 Neighboring gene uncharacterized LOC124905593 Neighboring gene uncharacterized LOC124908055 Neighboring gene APOB intestinal control region Neighboring gene Sharpr-MPRA regulatory region 2464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:21436748-21437248 Neighboring gene uncharacterized LOC105374317 Neighboring gene MPRA-validated peak3614 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr2:21488316-21488485 Neighboring gene uncharacterized LOC105374318

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LDL-cholesterol concentrations: a genome-wide association study. Sandhu MS, et al. Lancet, 2008 Feb 9. PMID 18262040, Free PMC Article
  2. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Hu Q, et al. Cell Res, 2019 Apr. PMID 30631154, Free PMC Article
  3. Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB. Li FL, et al. EMBO J, 2022 Sep 1. PMID 35844135, Free PMC Article
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. Drissi R, et al. Mol Cell Proteomics, 2015 Jul. PMID 25963833, Free PMC Article
  5. Panorama of ancient metazoan macromolecular complexes. Wan C, et al. Nature, 2015 Sep 17. PMID 26344197, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
tudor domain-containing protein 15
Names
tudor domain-containing protein 6-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306137.2 → NP_001293066.1  tudor domain-containing protein 15

    See identical proteins and their annotated locations for NP_001293066.1

    Status: VALIDATED

    Source sequence(s)
    AC010872
    Consensus CDS
    CCDS77385.1
    UniProtKB/Swiss-Prot
    B5MCY1
    Related
    ENSP00000384376.2, ENST00000405799.3
    Conserved Domains (2) summary
    cd04508
    Location:1346 → 1393
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:479 → 600
    TUDOR; Tudor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    21123932..21147325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533212.2 → XP_011531514.1  tudor domain-containing protein 15 isoform X1

    See identical proteins and their annotated locations for XP_011531514.1

    UniProtKB/Swiss-Prot
    B5MCY1
    Conserved Domains (2) summary
    cd04508
    Location:1346 → 1393
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:479 → 600
    TUDOR; Tudor domain

RNA

  1. XR_939798.3 RNA Sequence

  2. XR_001738578.2 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791767.1 Reference GRCh38.p14 PATCHES

    Range
    174600..197993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333002.1 → XP_054188977.1  tudor domain-containing protein 15 isoform X1

    UniProtKB/Swiss-Prot
    B5MCY1

RNA

  1. XR_008485814.1 RNA Sequence

  2. XR_008485813.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    21157138..21180528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340046.1 → XP_054196021.1  tudor domain-containing protein 15 isoform X1

RNA

  1. XR_008486237.1 RNA Sequence

  2. XR_008486236.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B5MCY1.1 GenPept UniProtKB/Swiss-Prot:B5MCY1

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials