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DEFB131B defensin beta 131B [ Homo sapiens (human) ]

Gene ID: 100129216, updated on 13-Aug-2022

Summary

Official Symbol
DEFB131Bprovided by HGNC
Official Full Name
defensin beta 131Bprovided by HGNC
Primary source
HGNC:HGNC:38058
See related
Ensembl:ENSG00000225805 AllianceGenome:HGNC:38058
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in defense response to bacterium and innate immune response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See DEFB131B in Genome Data Viewer
Location:
11q13.4
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (71878453..71884561)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (71805359..71811467)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71589499..71595607)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene XNDC1N-ZNF705EP-ALG1L9P readthrough Neighboring gene RNA, 5S ribosomal pseudogene 342 Neighboring gene defensin beta 130C (pseudogene) Neighboring gene XRCC1 N-terminal domain containing 1, N-terminal like Neighboring gene olfactory receptor family 7 subfamily E member 128 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
beta-defensin 131B
Names
defensin, beta 131

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242853.1NP_001229782.1  beta-defensin 131B precursor

    Status: INFERRED

    Source sequence(s)
    AP002495
    Consensus CDS
    CCDS76450.1
    UniProtKB/Swiss-Prot
    A0A096LNP1
    Related
    ENSP00000485141.1, ENST00000530210.1
    Conserved Domains (1) summary
    pfam13841
    Location:2857
    Defensin_beta_2; Beta defensin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    71878453..71884561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    71805359..71811467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)