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CIROP ciliated left-right organizer metallopeptidase [ Homo sapiens (human) ]

Gene ID: 100128908, updated on 4-Nov-2022

Summary

Official Symbol
CIROPprovided by HGNC
Official Full Name
ciliated left-right organizer metallopeptidaseprovided by HGNC
Primary source
HGNC:HGNC:53647
See related
Ensembl:ENSG00000283654 MIM:619703; AllianceGenome:HGNC:53647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HTX12; LMLN2
Summary
Predicted to enable peptidase activity. Predicted to be involved in cell adhesion and proteolysis. Predicted to be integral component of membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CIROP in Genome Data Viewer
Location:
14q11.2
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23099062..23104989, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17299696..17305634, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23568271..23574198, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene collagen alpha-2(I) chain-like Neighboring gene apoptotic chromatin condensation inducer 1 Neighboring gene uncharacterized LOC124903288 Neighboring gene chromosome 14 open reading frame 119 Neighboring gene CCAAT enhancer binding protein epsilon Neighboring gene solute carrier family 7 member 8 Neighboring gene RNA, U6 small nuclear 1138, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of left/right asymmetry ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ciliated left-right organizer metallopeptidase
Names
leishmanolysin homolog
leishmanolysin like peptidase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354640.2NP_001341569.1  ciliated left-right organizer metallopeptidase isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL117258
    Consensus CDS
    CCDS86373.1
    UniProtKB/Swiss-Prot
    A0A2R8Y3T5
    Related
    ENSP00000489869.1, ENST00000637218.2
    Conserved Domains (1) summary
    cl19482
    Location:254602
    Peptidase_M8; Leishmanolysin
  2. NM_001402427.1NP_001389356.1  ciliated left-right organizer metallopeptidase isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL117258

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23099062..23104989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17299696..17305634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001402357.1: Suppressed sequence

    Description
    NM_001402357.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.