U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

akap12 A-kinase anchoring protein 12 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100127584, updated on 4-Feb-2026
Official Symbol
akap12provided by Xenbase
Official Full Name
A-kinase anchoring protein 12provided by Xenbase
Primary source
Xenbase:XB-GENE-6459605
See related
Ensembl:ENSXETG00000037915 AllianceGenome:Xenbase:XB-GENE-6459605
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
Xgl; gravin; akap250
Summary
Predicted to enable calmodulin binding activity and protein kinase A binding activity. Predicted to be involved in regulation of protein kinase A signaling and signal transduction. Predicted to act upstream of or within positive regulation of protein kinase A signaling and regulation of protein kinase C signaling. Predicted to be located in membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See akap12 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
5
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 5 NC_030681.2 (44926570..44988664)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 5 NC_030681.1 (55114689..55176448)

Chromosome 5 - NC_030681.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100489674 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like Neighboring gene opsin 6, alpha Neighboring gene vitrin

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase A binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cAMP/PKA signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of protein kinase C signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
A-kinase anchor protein 12
Names
A kinase (PRKA) anchor protein 12
Xgravin-like

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030681.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    44926570..44988664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002934453.4 → XP_002934499.1  A-kinase anchor protein 12 isoform X1

    UniProtKB/TrEMBL
    A0A6I8SFS0, A0A803J3Q2
    Related
    ENSXETP00000093646.1, ENSXETT00000093970.2
    Conserved Domains (4) summary
    PTZ00121
    Location:235 → 816
    PTZ00121; MAEBL; Provisional
    PTZ00341
    Location:1931 → 2116
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    PRK10811
    Location:1743 → 1903
    rne; ribonuclease E; Reviewed
    pfam03832
    Location:594 → 621
    WSK; WSK motif

  2. XM_004914658.3 → XP_004914715.1  A-kinase anchor protein 12 isoform X2

    UniProtKB/TrEMBL
    A0A6I8QT52, A0A803J3Q2
    Related
    ENSXETP00000076536.1, ENSXETT00000066996.2
    Conserved Domains (4) summary
    PTZ00121
    Location:160 → 741
    PTZ00121; MAEBL; Provisional
    PTZ00341
    Location:1856 → 2041
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    PRK10811
    Location:1668 → 1828
    rne; ribonuclease E; Reviewed
    pfam03832
    Location:519 → 546
    WSK; WSK motif
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.