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HMBS hydroxymethylbilane synthase [ Felis catus (domestic cat) ]

Gene ID: 100127114, updated on 8-Mar-2024

Summary

Official Symbol
HMBS
Official Full Name
hydroxymethylbilane synthase
Primary source
VGNC:VGNC:67590
See related
EnsemblRapid:ENSFCTG00005024553
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
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Genomic context

See HMBS in Genome Data Viewer
Location:
chromosome: D1
Exon count:
15
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) D1 NC_058377.1 (16576086..16583945)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) D1 NC_018732.3 (16537348..16545198)

Chromosome D1 - NC_058377.1Genomic Context describing neighboring genes Neighboring gene hypoxia up-regulated 1 Neighboring gene VPS11 core subunit of CORVET and HOPS complexes Neighboring gene H2A.X variant histone Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1

Genomic regions, transcripts, and products

General gene information

Markers

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hydroxymethylbilane synthase activity IEA
Inferred from Electronic Annotation
more info
PubMed 
Process Evidence Code Pubs
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in peptidyl-pyrromethane cofactor linkage IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
porphobilinogen deaminase
NP_001171279.1
NP_001171280.1
XP_006936717.1
XP_006936718.1
XP_019666716.1
XP_044893954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177808.1NP_001171279.1  porphobilinogen deaminase isoform 1a

    See identical proteins and their annotated locations for NP_001171279.1

    Status: PROVISIONAL

    Source sequence(s)
    GQ850461
    UniProtKB/TrEMBL
    A0A5F5XNU0, D3W810, M3VW34
    Related
    ENSFCTP00005050036.1, ENSFCTT00005070241.1
    Conserved Domains (1) summary
    cd13645
    Location:20299
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold
  2. NM_001177809.1NP_001171280.1  porphobilinogen deaminase isoform 2a

    See identical proteins and their annotated locations for NP_001171280.1

    Status: PROVISIONAL

    Source sequence(s)
    GQ850463
    UniProtKB/TrEMBL
    A0A5F5XNU0, D3W812
    Conserved Domains (1) summary
    cd13645
    Location:3282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058377.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    16576086..16583945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_045038019.1XP_044893954.1  porphobilinogen deaminase isoform X2

    UniProtKB/TrEMBL
    A0A5F5XNU0
    Related
    ENSFCTP00005049882.1, ENSFCTT00005069966.1
    Conserved Domains (1) summary
    cd13645
    Location:20281
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold
  2. XM_006936655.4XP_006936717.1  porphobilinogen deaminase isoform X1

    See identical proteins and their annotated locations for XP_006936717.1

    UniProtKB/TrEMBL
    A0A5F5XNU0, D3W812
    Conserved Domains (1) summary
    cd13645
    Location:3282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold
  3. XM_006936656.2XP_006936718.1  porphobilinogen deaminase isoform X1

    See identical proteins and their annotated locations for XP_006936718.1

    UniProtKB/TrEMBL
    A0A5F5XNU0, D3W812
    Conserved Domains (1) summary
    cd13645
    Location:3282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold
  4. XM_019811157.2XP_019666716.1  porphobilinogen deaminase isoform X1

    UniProtKB/TrEMBL
    A0A5F5XNU0, D3W812
    Conserved Domains (1) summary
    cd13645
    Location:3282
    PBP2_HuPBGD_like; Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold

RNA

  1. XR_006585755.1 RNA Sequence