MET MET proto-oncogene, receptor tyrosine kinase [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: MET
Gene description: MET proto-oncogene, receptor tyrosine kinase
See related: Ensembl:ENSOCUG00000013060
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_11	current	mOryCun1.1 (GCF_964237555.1)	3	NC_091434.1 (152174488..152299481)
RS_2023_02	previous assembly	UM_NZW_1.0 (GCF_009806435.1)	7	NC_067380.1 (144962293..145086695)

Chromosome 3 - NC_091434.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results demonstrated hHGF gene transfer induced further overexpression of endogenous rHGF and c-Met mRNAs but lowered immunoreactivities of rHGF and c-Met in the neointima, thus leading to significant attenuation of neointimal hyperplasia.
Title: Overexpression of Hepatocyte Growth Factor mRNA Induced by Gene Transfer Attenuates Neointimal Hyperplasia After Balloon Injury.

Submit: New GeneRIF Correction

General gene information

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Markers

REN66164 (e-PCR)
- UniSTS:390964

ECD01585 (e-PCR)
- UniSTS:282687

GDB:176971 (e-PCR)
- UniSTS:154815

REN65840 (e-PCR)
- UniSTS:390640

ECD08731 (e-PCR)
- UniSTS:289779

ECD15421 (e-PCR)
- UniSTS:296438

Met (e-PCR), detects polymorphism
- UniSTS:143867

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in semaphorin-plexin signaling pathway involved in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of semaphorin receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hepatocyte growth factor receptor

Names: HGF receptor; HGF/SF receptor; SF receptor; c-Met; met proto-oncogene (hepatocyte growth factor receptor); met proto-oncogene tyrosine kinase; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met

NP_001164511.1

EC 2.7.10.1

XP_051703946.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171040.1 → NP_001164511.1 hepatocyte growth factor receptor precursor

See identical proteins and their annotated locations for NP_001164511.1

Status: PROVISIONAL

Source sequence(s)

DP000006

UniProtKB/Swiss-Prot

Q09YN5

UniProtKB/TrEMBL

A0A5F9DCS8

Related

ENSOCUP00000011247.2, ENSOCUT00000013064.4

Conserved Domains (8) summary

smart00423
Location:520 → 562

PSI; domain found in Plexins, Semaphorins and Integrins

smart00429
Location:839 → 932

IPT; ig-like, plexins, transcription factors

cd01179
Location:658 → 741

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:564 → 656

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:743 → 838

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd05058
Location:1083 → 1344

PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

pfam07714
Location:1079 → 1338

Pkinase_Tyr; Protein tyrosine kinase

cl15693
Location:25 → 517

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins