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VTRNA2-1 vault RNA 2-1 [ Homo sapiens (human) ]

Gene ID: 100126299, updated on 17-Jun-2024

Summary

Official Symbol
VTRNA2-1provided by HGNC
Official Full Name
vault RNA 2-1provided by HGNC
Primary source
HGNC:HGNC:37054
See related
Ensembl:ENSG00000270123 MIM:614938; AllianceGenome:HGNC:37054
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBL3; CBL-3; hvg-5; nc886; MIR886; VTRNA2; MIRN886; svtRNA2-1a; hsa-mir-886; pre-miR-886
Summary
This gene produces an RNA polymerase III transcript that resembles both a component of the ribonucleoprotein vault particle and a pre-microRNA. However, the RNA product does not function as a vault or microRNA; rather, it acts as a direct inhibitor of protein kinase R (also known as eukaryotic translation initiation factor 2-alpha kinase 2, EIF2AK2), and thereby plays an important role in the regulation of cell growth. This gene is located in the vicinity of a differentially methylated region (DMR) and is imprinted and may show allele-specific expression. This gene is also often hypermethylated and repressed in cancers. [provided by RefSeq, Nov 2015]
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Genomic context

See VTRNA2-1 in Genome Data Viewer
Location:
5q31.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (136080491..136080598, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (136603010..136603117, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (135416180..135416287, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23177 Neighboring gene transforming growth factor beta induced Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:135388921-135390120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16378 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16379 Neighboring gene SMAD5 antisense RNA 1 Neighboring gene SMAD family member 5 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:135488895-135490094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:135527733-135528647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135528804-135529321 Neighboring gene small integral membrane protein 32

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Other Names

  • cord blood lymphocyte-derived noncoding RNA 3
  • microRNA 886
  • noncoding RNA 886

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051612.1 RefSeqGene

    Range
    5001..5108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1104

RNA

  1. NR_030583.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC005219
    Related
    ENST00000602301.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    136080491..136080598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    136603010..136603117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)