U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rab1b RAB1B, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 100126191, updated on 24-Apr-2022

Summary

Official Symbol
Rab1bprovided by RGD
Official Full Name
RAB1B, member RAS oncogene familyprovided by RGD
Primary source
RGD:1642882
See related
Ensembl:ENSRNOG00000070897 AllianceGenome:RGD:1642882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rab1bl
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including autophagosome assembly; endoplasmic reticulum to Golgi vesicle-mediated transport; and regulation of autophagosome assembly. Is active in synapse. Orthologous to several human genes including RAB1B (RAB1B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 568.9), Kidney (RPKM 375.3) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rab1b in Genome Data Viewer
Location:
1q43
Exon count:
6
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202405759..202413850, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220483529..220491469, complement)

Chromosome 1 - NC_051336.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555354 Neighboring gene Yip1 interacting factor homolog A, membrane trafficking protein Neighboring gene cornichon family AMPA receptor auxiliary protein 2 Neighboring gene uncharacterized LOC120099979 Neighboring gene kinesin light chain 2 Neighboring gene phosphofurin acidic cluster sorting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC105830

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
 
involved_in Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in establishment of endothelial intestinal barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of glycoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in virion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in virion assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in phagophore assembly site membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras-related protein Rab-1B
Names
RAB1B-like, member RAS oncogene family
NP_001103449.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109979.3NP_001103449.1  ras-related protein Rab-1B

    See identical proteins and their annotated locations for NP_001103449.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000045
    UniProtKB/TrEMBL
    G3V6H0
    Related
    ENSRNOP00000091504.1, ENSRNOT00000100754.1
    Conserved Domains (1) summary
    cd01869
    Location:7172
    Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051336.1 Reference mRatBN7.2 Primary Assembly

    Range
    202405759..202413850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)