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Adat3 adenosine deaminase, tRNA-specific 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 100125374, updated on 6-Jul-2026
Official Symbol
Adat3provided by RGD
Official Full Name
adenosine deaminase, tRNA-specific 3provided by RGD
Primary source
RGD:1642417
See related
Ensembl:ENSRNOG00000063591 AllianceGenome:RGD:1642417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable catalytic activity and metal ion binding activity. Predicted to contribute to tRNA-specific adenosine-34 deaminase activity. Predicted to be involved in tRNA processing. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Spleen (RPKM 28.2), Adrenal (RPKM 26.8) and 9 other tissues See more
Orthologs
all
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See Adat3 in Genome Data Viewer
Location:
7q11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9759758..9761127, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9109070..9113673, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene BTB domain containing 2 Neighboring gene casein kinase 1, gamma 2 Neighboring gene secretory carrier membrane protein 4 Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene abhydrolase domain containing 17A, depalmitoylase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Clone Names

  • MGC112753

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
tRNA-specific adenosine-34 deaminase regulatory subunit ADAT3
Names
adenosine deaminase, tRNA-specific 3, TAD3 homolog
probable inactive tRNA-specific adenosine deaminase-like protein 3
tRNA-specific adenosine deaminase-like protein 3
tRNA-specific adenosine-34 deaminase subunit ADAT3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103361.1 → NP_001096831.1  tRNA-specific adenosine-34 deaminase regulatory subunit ADAT3

    See identical proteins and their annotated locations for NP_001096831.1

    Status: PROVISIONAL

    Source sequence(s)
    BC093394
    UniProtKB/Swiss-Prot
    Q561R2
    UniProtKB/TrEMBL
    A0A8I5XVX2
    Related
    ENSRNOP00000089590.1, ENSRNOT00000095368.2
    Conserved Domains (1) summary
    COG0590
    Location:195 → 345
    TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9759758..9761127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q561R2.1 GenPept UniProtKB/Swiss-Prot:Q561R2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials