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fgfr2 fibroblast growth factor receptor 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100124910, updated on 4-Nov-2022

Summary

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Official Symbol
fgfr2provided by Xenbase
Official Full Name
fibroblast growth factor receptor 2provided by Xenbase
Primary source
Xenbase:XB-GENE-1018296
See related
Ensembl:ENSXETG00000015592
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
bek; jws; cek3; cfd1; ect1; kgfr; tk14; tk25; bfr-1; cd332; k-sam; fgfr-2; xfgfr2
Orthologs
human mouse all
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Genomic context

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See fgfr2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
20
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 7 NC_030683.2 (19259481..19327949)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 7 NC_030683.1 (10932029..10999205)

Chromosome 7 - NC_030683.2Genomic Context describing neighboring genes Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene arginyltransferase 1 Neighboring gene U4 spliceosomal RNA Neighboring gene WD repeat domain 11 Neighboring gene phospholipid phosphatase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fibroblast growth factor receptor 2
NP_001096326.1
XP_012821350.1
XP_012821352.1
XP_012821353.1
XP_012821354.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102856.1 → NP_001096326.1  fibroblast growth factor receptor 2 precursor

    See identical proteins and their annotated locations for NP_001096326.1

    Status: PROVISIONAL

    Source sequence(s)
    BC135726
    UniProtKB/TrEMBL
    A4IHW8, F6YFR4
    Related
    ENSXETP00000091306.2, ENSXETT00000087442.2
    Conserved Domains (5) summary
    cd05857
    Location:175 → 259
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:282 → 371
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    cd05101
    Location:465 → 777
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam18123
    Location:382 → 412
    FGFR3_TM; Fibroblast growth factor receptor 3 transmembrane domain
    cl11960
    Location:64 → 136
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030683.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    19259481..19327949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012965896.2 → XP_012821350.1  fibroblast growth factor receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_012821350.1

    UniProtKB/TrEMBL
    A0A8J0SPM6
    Related
    ENSXETP00000075792.2, ENSXETT00000075774.2
    Conserved Domains (7) summary
    cd05857
    Location:175 → 259
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:282 → 371
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00409
    Location:185 → 259
    IG; Immunoglobulin
    smart00410
    Location:274 → 370
    IG_like; Immunoglobulin like
    cd05101
    Location:467 → 779
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:492 → 768
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:64 → 136
    Ig; Immunoglobulin domain

  2. XM_012965898.3 → XP_012821352.1  fibroblast growth factor receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8J0SHM8
    Related
    ENSXETP00000087394.2, ENSXETT00000078335.2
    Conserved Domains (7) summary
    cd04974
    Location:282 → 368
    Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
    cd05857
    Location:175 → 259
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00409
    Location:185 → 259
    IG; Immunoglobulin
    smart00410
    Location:274 → 368
    IG_like; Immunoglobulin like
    cd05101
    Location:467 → 779
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:492 → 768
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:64 → 136
    Ig; Immunoglobulin domain

  3. XM_012965899.3 → XP_012821353.1  fibroblast growth factor receptor 2 isoform X3

    UniProtKB/TrEMBL
    A0A8J0SS89
    Conserved Domains (6) summary
    cd05857
    Location:90 → 174
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:197 → 286
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00409
    Location:100 → 174
    IG; Immunoglobulin
    smart00410
    Location:189 → 285
    IG_like; Immunoglobulin like
    cd05101
    Location:382 → 694
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:407 → 683
    Pkinase_Tyr; Protein tyrosine kinase

  4. XM_012965900.3 → XP_012821354.1  fibroblast growth factor receptor 2 isoform X4

    UniProtKB/TrEMBL
    A0A8J0SR67
    Conserved Domains (5) summary
    cd05857
    Location:3 → 87
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:110 → 199
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00410
    Location:102 → 198
    IG_like; Immunoglobulin like
    cd05101
    Location:295 → 607
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:320 → 596
    Pkinase_Tyr; Protein tyrosine kinase
Nucleotide Protein Strain
Heading Accession and Version

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