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Mir743b microRNA 743b [ Mus musculus (house mouse) ]

Gene ID: 100124496, updated on 24-Sep-2025
Official Symbol
Mir743bprovided by MGI
Official Full Name
microRNA 743bprovided by MGI
Primary source
MGI:MGI:3718560
See related
Ensembl:ENSMUSG00000119547 miRBase:MI0005470; AllianceGenome:MGI:3718560
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mirn743b; mir-743b
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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See Mir743b in Genome Data Viewer
Location:
X A7.1; X 34.81 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (65820862..65820938, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (66777256..66777332, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase, liver/bone/kidney pseudogene Neighboring gene STARR-seq mESC enhancer starr_47293 Neighboring gene microRNA 743 Neighboring gene predicted gene 14681 Neighboring gene microRNA 742

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. LncRNA-NR_033515 promotes proliferation, fibrogenesis and epithelial-to-mesenchymal transition by targeting miR-743b-5p in diabetic nephropathy. Gao J, et al. Biomed Pharmacother, 2018 Oct. PMID 29990842
  2. miR-743b-3p promotes hepatic lipogenesis via branched-chain amino acids (BCAA) metabolism by targeting PPM1K in aged mice. Lu T, et al. Arch Gerontol Geriatr, 2024 Aug. PMID 38565071
  3. MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing. Ahn HW, et al. Mol Hum Reprod, 2010 Jul. PMID 20215419, Free PMC Article
  4. Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Chiang HR, et al. Genes Dev, 2010 May 15. PMID 20413612, Free PMC Article
  5. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-743b-3p promotes hepatic lipogenesis via branched-chain amino acids (BCAA) metabolism by targeting PPM1K in aged mice.
    Title: miR-743b-3p promotes hepatic lipogenesis via branched-chain amino acids (BCAA) metabolism by targeting PPM1K in aged mice.
  2. Suggest role for LncRNA-NR_033515 in promoting proliferation, fibrogenesis and epithelial-to-mesenchymal transition by targeting miR-743b-5p in diabetic nephropathy.
    Title: LncRNA-NR_033515 promotes proliferation, fibrogenesis and epithelial-to-mesenchymal transition by targeting miR-743b-5p in diabetic nephropathy.
Submit: New GeneRIF Correction

Other Names

  • microRNA Mirn743b
  • microRNA mir-743b
  • mmu-mir-743b

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_030535.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AL731773
    Related
    ENSMUST00000104763.4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    65820862..65820938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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