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CEP290 centrosomal protein 290 [ Felis catus (domestic cat) ]

Gene ID: 100113471, updated on 17-Aug-2024

Summary

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Official Symbol
CEP290
Official Full Name
centrosomal protein 290
Primary source
VGNC:VGNC:60771
See related
EnsemblRapid:ENSFCTG00005010889
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: B4
Exon count:
56
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) B4 NC_058374.1 (110277873..110371062, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) B4 NC_018729.3 (112514939..112607879, complement)

Chromosome B4 - NC_058374.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC123386666 Neighboring gene chromosome B4 C12orf50 homolog Neighboring gene RNA 5'-phosphate and 3'-OH ligase 1 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 3 Neighboring gene uncharacterized LOC123386670

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Widespread retinal degenerative disease mutation (rdAc) discovered among a large number of popular cat breeds. Menotti-Raymond M, et al. Vet J, 2010 Oct. PMID 19747862, Free PMC Article
  2. Mutation in CEP290 discovered for cat model of human retinal degeneration. Menotti-Raymond M, et al. J Hered, 2007 May-Jun. PMID 17507457
  3. Characterization of an Early-Onset, Autosomal Recessive, Progressive Retinal Degeneration in Bengal Cats. Ofri R, et al. Invest Ophthalmol Vis Sci, 2015 Aug. PMID 26258614, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in camera-type eye development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
centrosomal protein of 290 kDa
Names
centrosomal protein 290kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101658.1 → NP_001095128.1  centrosomal protein of 290 kDa

    See identical proteins and their annotated locations for NP_001095128.1

    Status: PROVISIONAL

    Source sequence(s)
    EF028068
    UniProtKB/TrEMBL
    A0A5K1VHI3, A6Y7R7, M3X5W5
    Related
    ENSFCTP00005020261.1, ENSFCTT00005030874.1
    Conserved Domains (4) summary
    COG1196
    Location:1640 → 2394
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1096 → 1890
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06273
    Location:85 → 133
    eIF-4B; Plant specific eukaryotic initiation factor 4B
    pfam16574
    Location:1289 → 1416
    CEP209_CC5; Coiled-coil region of centrosome protein CE290

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058374.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    110277873..110371062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023256244.2 → XP_023112012.2  centrosomal protein of 290 kDa isoform X2

    UniProtKB/TrEMBL
    A0A5K1VHI3
    Related
    ENSFCTP00005020527.1, ENSFCTT00005031224.1
    Conserved Domains (2) summary
    COG1196
    Location:86 → 1007
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1081 → 1883
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_023256243.2 → XP_023112011.2  centrosomal protein of 290 kDa isoform X1

    UniProtKB/TrEMBL
    A0A5K1VHI3
    Related
    ENSFCTP00005020389.1, ENSFCTT00005031044.1
    Conserved Domains (2) summary
    COG1196
    Location:86 → 1014
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1088 → 1890
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_023256245.2 → XP_023112013.2  centrosomal protein of 290 kDa isoform X3

    UniProtKB/TrEMBL
    A0A5K1VHI3
    Related
    ENSFCTP00005020082.1, ENSFCTT00005030627.1
    Conserved Domains (2) summary
    COG1196
    Location:1640 → 2469
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1096 → 1890
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_023256246.2 → XP_023112014.2  centrosomal protein of 290 kDa isoform X4

    UniProtKB/TrEMBL
    A0A5K1VHI3
    Related
    ENSFCTP00005019991.1, ENSFCTT00005030493.1
    Conserved Domains (2) summary
    COG1196
    Location:86 → 1014
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1088 → 1890
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_002743605.2 RNA Sequence

  2. XR_002743604.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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