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TMEM170B transmembrane protein 170B [ Homo sapiens (human) ]

Gene ID: 100113407, updated on 22-Sep-2022

Summary

Official Symbol
TMEM170Bprovided by HGNC
Official Full Name
transmembrane protein 170Bprovided by HGNC
Primary source
HGNC:HGNC:34244
See related
Ensembl:ENSG00000205269 AllianceGenome:HGNC:34244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Involved in negative regulation of canonical Wnt signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bone marrow (RPKM 11.1), brain (RPKM 9.1) and 21 other tissues See more
Orthologs
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Genomic context

See TMEM170B in Genome Data Viewer
Location:
6p24.2
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (11537749..11583524)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (11406440..11451893)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (11537982..11583757)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374928 Neighboring gene RNA, U1 small nuclear 64, pseudogene Neighboring gene THAP domain containing 12 pseudogene 5 Neighboring gene uncharacterized LOC340184 Neighboring gene small nucleolar RNA SNORA67 Neighboring gene uncharacterized LOC124901258 Neighboring gene androgen dependent TFPI regulating protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100829.3NP_001094299.1  transmembrane protein 170B

    See identical proteins and their annotated locations for NP_001094299.1

    Status: VALIDATED

    Source sequence(s)
    AL357518, BE670213, DB092520
    Consensus CDS
    CCDS43425.1
    UniProtKB/Swiss-Prot
    Q5T4T1
    Related
    ENSP00000368737.1, ENST00000379426.2
    Conserved Domains (1) summary
    pfam10190
    Location:28132
    Tmemb_170; Putative transmembrane protein 170

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    11537749..11583524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007059185.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    11406440..11451893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)