ins insulin [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: insprovided by Xenbase
Official Full Name: insulinprovided by Xenbase
Primary source: Xenbase:XB-GENE-485905
See related: AllianceGenome:Xenbase:XB-GENE-485905
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: ins1; xins; ins-a; ins-b; ins1-a
Summary: Predicted to enable hormone activity. Predicted to act upstream of or within glucose metabolic process. Predicted to be located in extracellular region. Is expressed in endoderm. Human ortholog(s) of this gene implicated in diabetic retinopathy; glucose metabolism disease (multiple); insulinoma; and pancreatic cancer. Orthologous to human INS (insulin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	4	NC_030680.2 (22179798..22185073, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	4	NC_030680.1 (12943084..12948359, complement)

Chromosome 4 - NC_030680.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucose metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: insulin

Names: insulin I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100236.1 → NP_001093706.1 insulin precursor

See identical proteins and their annotated locations for NP_001093706.1

Status: PROVISIONAL

Source sequence(s)

BC135265

UniProtKB/TrEMBL

A0A803KJL1, A4IGV9, F6QRS1

Conserved Domains (1) summary

cd04367
Location:25 → 106

IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...