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cd247 CD247 molecule [ Danio rerio (zebrafish) ]

Gene ID: 100101654, updated on 9-Sep-2025
Official Symbol
cd247provided by ZNC
Official Full Name
CD247 moleculeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061130-4
See related
AllianceGenome:ZFIN:ZDB-GENE-061130-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to act upstream of or within adaptive immune response and cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be part of plasma membrane protein complex. Is expressed in intestine; lymphocyte; ovary; and spleen. Human ortholog(s) of this gene implicated in immunodeficiency 25. Orthologous to human CD247 (CD247 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
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See cd247 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 1 NC_133176.1 (341686..354688, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_018394426.1 (30383..31814, complement)

Chromosome 1 - NC_133176.1Genomic Context describing neighboring genes Neighboring gene POU class 2 homeobox 1a Neighboring gene wu:fj30f06 Neighboring gene cellular repressor of E1A-stimulated genes 1 Neighboring gene H2A histone family member 1a like

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Impairment of the immune system in GH-overexpressing transgenic zebrafish (Danio rerio). Batista CR, et al. Fish Shellfish Immunol, 2014 Feb. PMID 24406293
  2. Effects of somatotrophic axis (GH/GHR) double transgenesis on structural and molecular aspects of the zebrafish immune system. Batista CR, et al. Fish Shellfish Immunol, 2015 Aug. PMID 26052013
  3. Single-cell transcriptional analysis reveals ILC-like cells in zebrafish. Hernández PP, et al. Sci Immunol, 2018 Nov 16. PMID 30446505, Free PMC Article
  4. Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish. Zhang B, et al. Transl Res, 2016 Apr. PMID 26746804
  5. The first wave of T lymphopoiesis in zebrafish arises from aorta endothelium independent of hematopoietic stem cells. Tian Y, et al. J Exp Med, 2017 Nov 6. PMID 28931624, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structure of the adaptor protein cd3zeta has been identified in the zebrafish genome.
    Title: Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptors.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of plasma membrane protein complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
T-cell surface glycoprotein CD3 zeta chain
Names
CD247 antigen
cd3zeta

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100157.1 → NP_001093627.1  T-cell surface glycoprotein CD3 zeta chain precursor

    See identical proteins and their annotated locations for NP_001093627.1

    Status: PROVISIONAL

    Source sequence(s)
    EF601086
    UniProtKB/TrEMBL
    A7KX13
    Conserved Domains (2) summary
    pfam02189
    Location:125 → 144
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam11628
    Location:27 → 56
    TCR_zetazeta; T-cell surface glycoprotein CD3 zeta chain

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133176.1 Reference GRCz12tu Primary Assembly

    Range
    341686..354688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
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