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MCTS2 MCTS family member 2 [ Homo sapiens (human) ]

Gene ID: 100101490, updated on 1-Mar-2024

Summary

Official Symbol
MCTS2provided by HGNC
Official Full Name
MCTS family member 2provided by HGNC
Primary source
HGNC:HGNC:49760
See related
Ensembl:ENSG00000101898 MIM:620406; AllianceGenome:HGNC:49760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCTS2P; PSIMCT-1
Summary
This locus represents a retrogene copy of MCTS1 (GeneID:28985) and contains an ORF similar to that parent gene. This locus is situated in a differentially methylated region (DMR) and transcripts in this region are imprinted. [provided by RefSeq, Nov 2021]
Orthologs
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Genomic context

See MCTS2 in Genome Data Viewer
Location:
20q11.21
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (31547379..31548081)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (33271603..33272305)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30135182..30135884)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene tRNA-Ser (anticodon AGA) 7-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12757 Neighboring gene CD24 molecule pseudogene 3 Neighboring gene histocompatibility minor 13 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:30134937-30136136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30137639-30138140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30138141-30138640 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30142553-30143052 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:30148388-30149587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30153591-30154466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:30154467-30155342 Neighboring gene Sharpr-MPRA regulatory region 9809 Neighboring gene HM13 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:30160423-30160964 Neighboring gene uncharacterized LOC107985416 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:30162848-30163017 Neighboring gene RNA, U6 small nuclear 384, pseudogene

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
malignant T-cell-amplified sequence 2
Names
MCTS family member 2, pseudogene
malignant T cell amplified sequence 1 pseudogene
malignant T cell amplified sequence 2, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397496.1NP_001384425.1  malignant T-cell-amplified sequence 2

    Status: VALIDATED

    Source sequence(s)
    AL110115
    Consensus CDS
    CCDS93025.1
    UniProtKB/Swiss-Prot
    A0A3B3IRV3
    Related
    ENSP00000496921.1, ENST00000394552.4
    Conserved Domains (2) summary
    cd11609
    Location:480
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    cd21155
    Location:80175
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    31547379..31548081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    33271603..33272305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_045217.2: Suppressed sequence

    Description
    NG_045217.2: This RefSeq was removed because it is now thought that this gene does encode a protein.
  2. NR_003677.1: Suppressed sequence

    Description
    NR_003677.1: This RefSeq was removed because there is insufficient evidence that this locus is transcribed independently of GeneID:81502.