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SPDYE12 speedy/RINGO cell cycle regulator family member E12 [ Homo sapiens (human) ]

Gene ID: 100101268, updated on 10-Oct-2023

Summary

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Official Symbol
SPDYE12provided by HGNC
Official Full Name
speedy/RINGO cell cycle regulator family member E12provided by HGNC
Primary source
HGNC:HGNC:51508
See related
Ensembl:ENSG00000184616 AllianceGenome:HGNC:51508
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPDYE12P
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Genomic context

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See SPDYE12 in Genome Data Viewer
Location:
7q11.23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (74904289..74915078, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (76106594..76117387, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (74320394..74331167, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Williams-Beuren syndrome medial block B recombination region Neighboring gene GTF2I repeat domain containing 2 Neighboring gene uncharacterized LOC124901673 Neighboring gene STAG3 cohesin complex component like 2 (pseudogene) Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 5 Neighboring gene uncharacterized LOC105375352 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18289 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:74387918-74388452 Neighboring gene cytosolic arginine sensor for mTORC1 subunit 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:74408133-74408753 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:74836976-74837481 Neighboring gene RCC1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
speedy protein E12
Names
Williams Beuren syndrome chromosome region 19 pseudogene
speedy homolog E1 pseudogene
speedy/RINGO cell cycle regulator family member E1 pseudogene
speedy/RINGO cell cycle regulator family member E12, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382555.2 → NP_001369484.1  speedy protein E12

    Status: VALIDATED

    Source sequence(s)
    AC211424
    Consensus CDS
    CCDS94123.1
    UniProtKB/Swiss-Prot
    P0DUX1
    Related
    ENSP00000510197.1, ENST00000618416.5
    Conserved Domains (1) summary
    pfam11357
    Location:107 → 261
    Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    74904289..74915078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419678.1 → XP_047275634.1  speedy protein E12 isoform X1

    UniProtKB/Swiss-Prot
    P0DUX1
    Conserved Domains (1) summary
    pfam11357
    Location:107 → 261
    Spy1; Cell cycle regulatory protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    76106594..76117387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_006250.3: Suppressed sequence

    Description
    NG_006250.3: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DUX1.1 GenPept UniProtKB/Swiss-Prot:P0DUX1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials