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BRAF B-Raf proto-oncogene, serine/threonine kinase [ Ornithorhynchus anatinus (platypus) ]

Gene ID: 100086380, updated on 8-Mar-2024

Summary

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Gene symbol
BRAF
Gene description
B-Raf proto-oncogene, serine/threonine kinase
See related
Ensembl:ENSOANG00000013389
Gene type
protein coding
RefSeq status
MODEL
Organism
Ornithorhynchus anatinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
20
Annotation release Status Assembly Chr Location
105 current mOrnAna1.pri.v4 (GCF_004115215.2) 10 NC_041737.1 (51833914..51952194)

Chromosome 10 - NC_041737.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 178B Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene aarF domain containing kinase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_041737.1 Chromosome 10 Reference mOrnAna1.pri.v4 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase B-raf
Names
v-raf murine sarcoma viral oncogene homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ornithorhynchus anatinus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrnAna1.pri.v4 Primary Assembly

Genomic

  1. NC_041737.1 Reference mOrnAna1.pri.v4 Primary Assembly

    Range
    51833914..51952194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029073227.2 → XP_028929060.1  serine/threonine-protein kinase B-raf isoform X4

    UniProtKB/TrEMBL
    A0A6I8NBK8
    Related
    ENSOANP00000038180.1
    Conserved Domains (3) summary
    cd14062
    Location:444 → 696
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:216 → 261
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cd17134
    Location:135 → 213
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

  2. XM_029073225.2 → XP_028929058.1  serine/threonine-protein kinase B-raf isoform X2

    UniProtKB/TrEMBL
    F7DEX8
    Conserved Domains (3) summary
    cd14062
    Location:484 → 736
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:216 → 261
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cd17134
    Location:135 → 213
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

  3. XM_029073228.2 → XP_028929061.1  serine/threonine-protein kinase B-raf isoform X1

    UniProtKB/TrEMBL
    F7DEX8
    Related
    ENSOANP00000021130.5
    Conserved Domains (3) summary
    cd14062
    Location:484 → 736
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:216 → 261
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cd17134
    Location:135 → 213
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF

  4. XM_029073226.2 → XP_028929059.1  serine/threonine-protein kinase B-raf isoform X3

    UniProtKB/TrEMBL
    A0A6I8NF87
    Related
    ENSOANP00000039893.1
    Conserved Domains (3) summary
    cd14062
    Location:444 → 696
    STKc_Raf; Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases
    pfam00130
    Location:216 → 261
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cd17134
    Location:135 → 213
    RBD_BRAF; Ras-binding domain (RBD) found in serine/threonine-protein kinase BRAF
Nucleotide Protein
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