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TNKS2 tankyrase 2 [ Ornithorhynchus anatinus (platypus) ]

Gene ID: 100075689, updated on 18-Sep-2024

Summary

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Gene symbol
TNKS2
Gene description
tankyrase 2
See related
Ensembl:ENSOANG00000000256
Gene type
protein coding
RefSeq status
MODEL
Organism
Ornithorhynchus anatinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus
Orthologs
human mouse all
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Genomic context

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See TNKS2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
27
Annotation release Status Assembly Chr Location
105 current mOrnAna1.pri.v4 (GCF_004115215.2) 3 NC_041730.1 (48348312..48408747, complement)

Chromosome 3 - NC_041730.1Genomic Context describing neighboring genes Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene B-TFIID TATA-box binding protein associated factor 1 Neighboring gene uncharacterized LOC114810139 Neighboring gene small nucleolar RNA SNORD97 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component Neighboring gene eukaryotic translation initiation factor 4 gamma 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_041730.1 Chromosome 3 Reference mOrnAna1.pri.v4 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
poly [ADP-ribose] polymerase tankyrase-2
Names
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Ornithorhynchus anatinus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOrnAna1.pri.v4 Primary Assembly

Genomic

  1. NC_041730.1 Reference mOrnAna1.pri.v4 Primary Assembly

    Range
    48348312..48408747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029059991.1 → XP_028915824.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X2

    Conserved Domains (7) summary
    PHA02876
    Location:67 → 418
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:852 → 917
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:475 → 783
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:919 → 1141
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:509 → 537
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:37 → 90
    Ank_5; Ankyrin repeats (many copies)
    pfam00023
    Location:414 → 443
    Ank; Ankyrin repeat

  2. XM_029059992.1 → XP_028915825.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X3

    Conserved Domains (7) summary
    PHA02876
    Location:67 → 431
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:865 → 930
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:488 → 796
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:932 → 1132
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:522 → 550
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:37 → 90
    Ank_5; Ankyrin repeats (many copies)
    pfam00023
    Location:427 → 456
    Ank; Ankyrin repeat

  3. XM_029059990.1 → XP_028915823.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X1

    UniProtKB/TrEMBL
    F6YUF4
    Related
    ENSOANP00000000439.2, ENSOANT00000000439.3
    Conserved Domains (7) summary
    PHA02876
    Location:67 → 431
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:865 → 930
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:488 → 796
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:932 → 1154
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:522 → 550
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:37 → 90
    Ank_5; Ankyrin repeats (many copies)
    pfam00023
    Location:427 → 456
    Ank; Ankyrin repeat
Nucleotide Protein
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