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ST14 ST14 transmembrane serine protease matriptase [ Equus caballus (horse) ]

Gene ID: 100072676, updated on 8-Aug-2025
Official Symbol
ST14provided by VGNC
Official Full Name
ST14 transmembrane serine protease matriptaseprovided by VGNC
Primary source
VGNC:VGNC:23625
See related
Ensembl:ENSECAG00000006391
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
all
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Try the new Transcripts and proteins table
See ST14 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_12 current TB-T2T (GCF_041296265.1) 7 NC_091690.1 (39207523..39246993)
RS_2024_08 previous assembly EquCab3.0 (GCF_002863925.1) 7 NC_009150.3 (39689396..39728855)

Chromosome 7 - NC_091690.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC138925284 Neighboring gene amyloid beta precursor like protein 2 Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene uncharacterized LOC102150322 Neighboring gene uncharacterized LOC138925001 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 8

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Thoroughbred Stallion gene expression
  • BioProject: PRJEB53382
  • Analysis date: Mon Jan 06 09:53:19 2025

Related articles in PubMed

  1. A Nonsense Variant in the ST14 Gene in Akhal-Teke Horses with Naked Foal Syndrome. Bauer A, et al. G3 (Bethesda), 2017 Apr 3. PMID 28235824, Free PMC Article
  2. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the identified equine ST14:c.388G>T variant is an excellent candidate causative variant for Naked foal syndrome.
    Title: A Nonsense Variant in the ST14 Gene in Akhal-Teke Horses with Naked Foal Syndrome.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in acrosome reaction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
suppressor of tumorigenicity 14 protein
Names
suppression of tumorigenicity 14

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_041296265.1-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference TB-T2T Primary Assembly

Genomic

  1. NC_091690.1 Reference TB-T2T Primary Assembly

    Range
    39207523..39246993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023645141.2 → XP_023500909.1  suppressor of tumorigenicity 14 protein

    UniProtKB/TrEMBL
    F7BW05
    Related
    ENSECAP00000005022.3
    Conserved Domains (4) summary
    cd00041
    Location:340 → 444
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:525 → 559
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:615 → 852
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam01390
    Location:88 → 171
    SEA; SEA domain
Nucleotide Protein
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