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GNPDA1 glucosamine-6-phosphate deaminase 1 [ Homo sapiens (human) ]

Gene ID: 10007, updated on 11-Sep-2019

Summary

Official Symbol
GNPDA1provided by HGNC
Official Full Name
glucosamine-6-phosphate deaminase 1provided by HGNC
Primary source
HGNC:HGNC:4417
See related
Ensembl:ENSG00000113552 MIM:601798
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPI; HLN; GNP1; GNPI; GNPDA
Summary
Glucosamine-6-phosphate deaminase (EC 3.5.99.6) is an allosteric enzyme that catalyzes the reversible conversion of D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium (Arreola et al., 2003 [PubMed 12965206]).[supplied by OMIM, Jan 2010]
Expression
Ubiquitous expression in kidney (RPKM 29.0), urinary bladder (RPKM 18.6) and 24 other tissues See more
Orthologs

Genomic context

See GNPDA1 in Genome Data Viewer
Location:
5q31.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (142000671..142013027, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141380234..141392620, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene DAP3 binding cell death enhancer 1 Neighboring gene protocadherin 12 Neighboring gene ring finger protein 14 Neighboring gene mitochondrial ribosomal protein L11 pseudogene 2 Neighboring gene uncharacterized LOC105378204

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0060

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glucosamine-6-phosphate deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucosamine-6-phosphate deaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
N-acetylglucosamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-acetylneuraminate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
UDP-N-acetylglucosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
generation of precursor metabolites and energy IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucosamine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucosamine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucosamine catabolic process TAS
Traceable Author Statement
more info
 
single fertilization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
glucosamine-6-phosphate isomerase 1
Names
GNPDA 1
glcN6P deaminase 1
oscillin
NP_005462.1
XP_005268405.1
XP_006714810.1
XP_011535839.1
XP_024310087.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005471.5NP_005462.1  glucosamine-6-phosphate isomerase 1

    See identical proteins and their annotated locations for NP_005462.1

    Status: VALIDATED

    Source sequence(s)
    AC005740, BC022322, CA432951
    Consensus CDS
    CCDS4272.1
    UniProtKB/Swiss-Prot
    P46926
    Related
    ENSP00000311876.6, ENST00000311337.11
    Conserved Domains (1) summary
    cl00339
    Location:1253
    SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    142000671..142013027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714747.2XP_006714810.1  glucosamine-6-phosphate isomerase 1 isoform X2

    See identical proteins and their annotated locations for XP_006714810.1

    UniProtKB/Swiss-Prot
    P46926
    Related
    ENSP00000424275.1, ENST00000500692.6
    Conserved Domains (1) summary
    cl00339
    Location:1253
    SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...
  2. XM_024454319.1XP_024310087.1  glucosamine-6-phosphate isomerase 1 isoform X2

    Related
    ENSP00000423485.1, ENST00000503794.5
    Conserved Domains (1) summary
    cl00339
    Location:1253
    SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...
  3. XM_011537537.1XP_011535839.1  glucosamine-6-phosphate isomerase 1 isoform X2

    See identical proteins and their annotated locations for XP_011535839.1

    UniProtKB/Swiss-Prot
    P46926
    Conserved Domains (1) summary
    cl00339
    Location:1253
    SugarP_isomerase; SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ...
  4. XM_005268348.1XP_005268405.1  glucosamine-6-phosphate isomerase 1 isoform X1

    Conserved Domains (1) summary
    PRK00443
    Location:30287
    nagB; glucosamine-6-phosphate deaminase; Provisional
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