PPIB peptidylprolyl isomerase B [Equus caballus (horse)] - Gene

Summary

Official Symbol: PPIBprovided by VGNC
Official Full Name: peptidylprolyl isomerase Bprovided by VGNC
Primary source: VGNC:VGNC:21728
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	TB-T2T (GCF_041296265.1)	1	NC_091684.1 (141123611..141129529)
RS_2024_08	previous assembly	EquCab3.0 (GCF_002863925.1)	1	NC_009144.3 (129306966..129312884)

Chromosome 1 - NC_091684.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Thoroughbred Stallion gene expression
BioProject: PRJEB53382
Analysis date: Mon Jan 06 09:53:19 2025

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the mutation in cyclophilin B (CypB) locally rearranges the flexible N-terminal end of the polypeptide chain and also makes it more rigid.
Title: Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse.
Mutation in cyclophilin B that causes hyperelastosis cutis in American Quarter Horse does not affect peptidylprolyl cis-trans isomerase activity but shows altered cyclophilin B-protein interactions and affects collagen folding
Title: Mutation in cyclophilin B that causes hyperelastosis cutis in American Quarter Horse does not affect peptidylprolyl cis-trans isomerase activity but shows altered cyclophilin B-protein interactions and affects collagen folding.
The prevalence of a previously described mutation in cyclophilin B (a causal candidate gene for hereditary equine regional dermal asthenia) among Quarter Horses in France was determined to be 1.6%.
Title: Prevalence of the mutation in cyclophilin B (PPIB), a causal candidate gene for HERDA, among Quarter Horses in France.
A missense mutation in cyclophilin B (PPIB) is reported as a novel, causal candidate gene for hereditary equine regional dermal asthenia (HERDA).
Title: Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse.

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General gene information

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Markers

Ppib (e-PCR), detects polymorphism
- UniSTS:144252

MARC_7211-7212:992008294:1 (e-PCR)
- UniSTS:231310

MARC_7211-7212:996687645:1 (e-PCR)
- UniSTS:231310

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein folding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase B

NP_001093231.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099761.1 → NP_001093231.1 peptidyl-prolyl cis-trans isomerase B

See identical proteins and their annotated locations for NP_001093231.1

Status: PROVISIONAL

Source sequence(s)

EF397503

UniProtKB/TrEMBL

A5YBL8

Conserved Domains (1) summary

cd01926
Location:45 → 203

cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...