FKBP6 FKBP prolyl isomerase family member 6 (inactive) [Equus caballus (horse)] - Gene

Summary

Official Symbol: FKBP6provided by VGNC
Official Full Name: FKBP prolyl isomerase family member 6 (inactive)provided by VGNC
Primary source: VGNC:VGNC:18053
See related: Ensembl:ENSECAG00000017859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as: FKBP-6; FKBP36
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	TB-T2T (GCF_041296265.1)	13	NC_091696.1 (12328766..12356801)
RS_2024_08	previous assembly	EquCab3.0 (GCF_002863925.1)	13	NC_009156.3 (11350273..11378301)

Chromosome 13 - NC_091696.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Thoroughbred Stallion gene expression
BioProject: PRJEB53382
Analysis date: Mon Jan 06 09:53:19 2025

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Thoroughbred stallion fertility is significantly associated with FKBP6 genotype but not with inbreeding or the contribution of a leading sire.
Title: Thoroughbred stallion fertility is significantly associated with FKBP6 genotype but not with inbreeding or the contribution of a leading sire.
In conclusion, in Hanoverian stallions, the FKBP6-associated SNP g.11040379C>A confers higher conception rates in A/A homozygous and lower conception rates in C/C homozygous Hanoverian stallions.
Title: Implication of FKBP6 for male fertility in horses.
In conclusion, FKBP6 was considered a susceptibility gene of incomplete penetrance for impaired acrosomal reaction in stallions and a candidate gene for male subfertility
Title: Genome-wide association study implicates testis-sperm specific FKBP6 as a susceptibility locus for impaired acrosome reaction in stallions.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in piRNA processing	IEA Inferred from Electronic Annotation more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: inactive peptidyl-prolyl cis-trans isomerase FKBP6

Names: 36 kDa FK506-binding protein; FK506 binding protein 6, 36kDa; FK506-binding protein 6; FKBP prolyl isomerase 6; Immunophilin FKBP36; Inactive PPIase FKBP6; Inactive peptidyl-prolyl cis-trans isomerase FKBP6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.