U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KMT2D lysine methyltransferase 2D [ Equus caballus (horse) ]

Gene ID: 100058932, updated on 8-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
KMT2D
Gene description
lysine methyltransferase 2D
See related
Ensembl:ENSECAG00000017946
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as
ALR
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See KMT2D in Genome Data Viewer
Location:
chromosome: 6
Exon count:
56
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 6 NC_009149.3 (67722353..67762390, complement)
102 previous assembly EquCab2.0 (GCF_000002305.2) 6 NC_009149.2 (66825221..66864332, complement)

Chromosome 6 - NC_009149.3Genomic Context describing neighboring genes Neighboring gene dendrin Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 1 Neighboring gene RHEB like 1 Neighboring gene desert hedgehog signaling molecule

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K4 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of MLL3/4 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
histone-lysine N-methyltransferase 2D

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009149.3 Reference EquCab3.0 Primary Assembly

    Range
    67722353..67762390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023643477.1 → XP_023499245.1  histone-lysine N-methyltransferase 2D isoform X5

    UniProtKB/TrEMBL
    A0A9L0RW12
    Conserved Domains (14) summary
    smart00398
    Location:2041 → 2092
    HMG; high mobility group
    smart00542
    Location:4571 → 4658
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:4744 → 4866
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4868 → 4884
    PostSET; Cysteine-rich motif following a subset of SET domains
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1446 → 1492
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1395 → 1445
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1523 → 1573
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:4363 → 4469
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:4512 → 4563
    FYRN; F/Y-rich N-terminus
    pfam09606
    Location:3306 → 3670
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily
    cl26464
    Location:672 → 1170
    Atrophin-1; Atrophin-1 family

  2. XM_023643475.1 → XP_023499243.1  histone-lysine N-methyltransferase 2D isoform X3

    UniProtKB/TrEMBL
    A0A9L0RW12, F6R2B8
    Conserved Domains (14) summary
    smart00398
    Location:2040 → 2091
    HMG; high mobility group
    smart00542
    Location:4593 → 4680
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:4766 → 4888
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4890 → 4906
    PostSET; Cysteine-rich motif following a subset of SET domains
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1445 → 1491
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1394 → 1444
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1522 → 1572
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:4385 → 4491
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:4534 → 4585
    FYRN; F/Y-rich N-terminus
    pfam09606
    Location:3305 → 3669
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily
    cl26464
    Location:672 → 1170
    Atrophin-1; Atrophin-1 family

  3. XM_023643476.1 → XP_023499244.1  histone-lysine N-methyltransferase 2D isoform X4

    UniProtKB/TrEMBL
    A0A9L0RW12
    Conserved Domains (14) summary
    smart00398
    Location:2034 → 2085
    HMG; high mobility group
    smart00542
    Location:4587 → 4674
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:4760 → 4882
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4884 → 4900
    PostSET; Cysteine-rich motif following a subset of SET domains
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1446 → 1492
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1395 → 1445
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1523 → 1573
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:4379 → 4485
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:4528 → 4579
    FYRN; F/Y-rich N-terminus
    pfam09606
    Location:3299 → 3663
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily
    cl26464
    Location:672 → 1170
    Atrophin-1; Atrophin-1 family

  4. XM_023643478.1 → XP_023499246.1  histone-lysine N-methyltransferase 2D isoform X6

    UniProtKB/TrEMBL
    A0A9L0RW12
    Conserved Domains (14) summary
    smart00398
    Location:2041 → 2092
    HMG; high mobility group
    smart00542
    Location:4563 → 4650
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:4736 → 4858
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4860 → 4876
    PostSET; Cysteine-rich motif following a subset of SET domains
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1446 → 1492
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1395 → 1445
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1523 → 1573
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:4355 → 4461
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:4504 → 4555
    FYRN; F/Y-rich N-terminus
    pfam09606
    Location:3275 → 3639
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily
    cl26464
    Location:672 → 1170
    Atrophin-1; Atrophin-1 family

  5. XM_023643479.1 → XP_023499247.1  histone-lysine N-methyltransferase 2D isoform X7

    UniProtKB/TrEMBL
    A0A9L0RW12
    Conserved Domains (14) summary
    smart00398
    Location:2041 → 2092
    HMG; high mobility group
    smart00542
    Location:4531 → 4618
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:4704 → 4826
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4828 → 4844
    PostSET; Cysteine-rich motif following a subset of SET domains
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1446 → 1492
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1395 → 1445
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1523 → 1573
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:4323 → 4429
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:4472 → 4523
    FYRN; F/Y-rich N-terminus
    pfam09606
    Location:3306 → 3670
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily
    cl26464
    Location:672 → 1170
    Atrophin-1; Atrophin-1 family

  6. XM_023643474.1 → XP_023499242.1  histone-lysine N-methyltransferase 2D isoform X2

    UniProtKB/TrEMBL
    A0A9L0RW12
    Conserved Domains (14) summary
    smart00398
    Location:2041 → 2092
    HMG; high mobility group
    smart00542
    Location:4594 → 4681
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:4767 → 4889
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:4891 → 4907
    PostSET; Cysteine-rich motif following a subset of SET domains
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1446 → 1492
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1395 → 1445
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1523 → 1573
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:4386 → 4492
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:4535 → 4586
    FYRN; F/Y-rich N-terminus
    pfam09606
    Location:3306 → 3670
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily
    cl26464
    Location:672 → 1170
    Atrophin-1; Atrophin-1 family

  7. XM_005611139.3 → XP_005611196.2  histone-lysine N-methyltransferase 2D isoform X1

    UniProtKB/TrEMBL
    A0A9L0RW12
    Related
    ENSECAP00000066791.1, ENSECAT00000090281.1
    Conserved Domains (14) summary
    smart00398
    Location:2038 → 2089
    HMG; high mobility group
    smart00542
    Location:5264 → 5351
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:5421 → 5543
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    smart00508
    Location:5545 → 5561
    PostSET; Cysteine-rich motif following a subset of SET domains
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1446 → 1492
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1395 → 1445
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1523 → 1573
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5056 → 5162
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5205 → 5256
    FYRN; F/Y-rich N-terminus
    pfam09606
    Location:4019 → 4340
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily
    cl26464
    Location:672 → 1170
    Atrophin-1; Atrophin-1 family
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.