HBB hemoglobin, beta [Equus caballus (horse)] - Gene

Summary

Gene symbol: HBB
Gene description: hemoglobin, beta
See related: Ensembl:ENSECAG00000010020
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as: GLNA1
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Genomic context

Location:: chromosome: 7

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	TB-T2T (GCF_041296265.1)	7	NC_091690.1 (76380365..76381561, complement)
RS_2024_08	previous assembly	EquCab3.0 (GCF_002863925.1)	7	NC_009150.3 (76113910..76115106, complement)

Chromosome 7 - NC_091690.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Thoroughbred Stallion gene expression
BioProject: PRJEB53382
Analysis date: Mon Jan 06 09:53:19 2025

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study presents comparison of two neutron structures of hemoglobins, human deoxyhemoglobin (T state) and equine cyanomethemoglobin (R state) and offers a direct observation of histidine residues that are likely to contribute to the Bohr effect.
Title: Visualizing the Bohr effect in hemoglobin: neutron structure of equine cyanomethemoglobin in the R state and comparison with human deoxyhemoglobin in the T state.
cyanomethemoglobin is in the R state and preliminary room-temperature electron and neutron scattering density maps clearly show the protonation states of potential Bohr groups.
Title: Preliminary neutron and X-ray crystallographic studies of equine cyanomethemoglobin.

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General gene information

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Markers

Hbb-b1 (e-PCR), detects polymorphism
- UniSTS:499134

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables haptoglobin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info	PubMed
enables hemoglobin alpha binding	IEA Inferred from Electronic Annotation more info	PubMed
enables organic acid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxygen binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peroxidase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in oxygen transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in blood microparticle	IEA Inferred from Electronic Annotation more info	PubMed
part_of haptoglobin-hemoglobin complex	IEA Inferred from Electronic Annotation more info	PubMed
part_of hemoglobin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: hemoglobin subunit beta

Names: beta-globin; beta-hemoglobin; globin A1; hemoglobin beta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.